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| Content Provider | PubMed Central |
|---|---|
| Author | Jiang, Qiu-ju Chen, Weiwei Dan, Hong Tan, Li Zhu, He Yang, Guangzhong Shen, Jinhua Peng, Yong-bo Zhao, Ping Xue, Lu Yu, Meng-fei Ma, Liqun Si, Xiao-tang Wang, Zhuo Dai, Jiapei Qin, Gangjian Zou, Chunbin Liu, Qing-hua |
| Copyright Year | 2016 |
| Abstract | Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C. phellodendri has similar relaxant action was unclear. An n-butyl alcohol extract of C. phellodendri (NBAECP, nonberberine component) was prepared, which completely inhibits high K+- and acetylcholine- (ACH-) induced precontraction of airway smooth muscle in tracheal rings and lung slices from control and asthmatic mice, respectively. The contraction induced by high K+ was also blocked by nifedipine, a selective blocker of L-type Ca2+ channels. The ACH-induced contraction was partially inhibited by nifedipine and pyrazole 3, an inhibitor of TRPC3 and STIM/Orai channels. Taken together, our data demonstrate that NBAECP can relax ASM by inhibiting L-type Ca2+ channels and TRPC3 and/or STIM/Orai channels, suggesting that NBAECP could be developed to a new drug for relieving bronchospasm. |
| Related Links | http://dx.doi.org/10.1155/2016/8703239 |
| Starting Page | 8703239 |
| File Format | |
| ISSN | 17414288 |
| e-ISSN | 17414288 |
| Journal | Evidence-based Complementary and Alternative Medicine : eCAM |
| Volume Number | 2016 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Complementary and Alternative Medicine |
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