NDLI: A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research

Content Provider	PubMed Central
Author	Rinchai, Darawan Sabri, Boughorbel Presnell, Scott Quinn, Charlie Chaussabel, Damien
Copyright Year	2016
Abstract	Systems-scale profiling approaches have become widely used in translational research settings. The resulting accumulation of large-scale datasets in public repositories represents a critical opportunity to promote insight and foster knowledge discovery. However, resources that can serve as an interface between biomedical researchers and such vast and heterogeneous dataset collections are needed in order to fulfill this potential. Recently, we have developed an interactive data browsing and visualization web application, the Gene Expression Browser (GXB). This tool can be used to overlay deep molecular phenotyping data with rich contextual information about analytes, samples and studies along with ancillary clinical or immunological profiling data. In this note, we describe a curated compendium of 93 public datasets generated in the context of human monocyte immunological studies, representing a total of 4,516 transcriptome profiles. Datasets were uploaded to an instance of GXB along with study description and sample annotations. Study samples were arranged in different groups. Ranked gene lists were generated based on relevant group comparisons. This resource is publicly available online athttp://monocyte.gxbsidra.org/dm3/landing.gsp.
Related Links	http://dx.doi.org/10.12688/f1000research.8182.2
Starting Page	291
File Format	PDF
ISSN	20461402
e-ISSN	20461402
Journal	F1000Research
Volume Number	5
Language	English
Publisher	F1000Research
Publisher Date	2016-04-25
Access Restriction	Open
Rights Holder	F1000Research
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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