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| Content Provider | PubMed Central |
|---|---|
| Author | Schoenfelder, Stefan Sugar, Robert Dimond, Andrew Javierre, Biola-maria Armstrong, Harry Mifsud, Borbala Dimitrova, Emilia Matheson, Louise Filipe, Tavares-cadete Furlan-magaril, Mayra Anne, Segonds-pichon Jurkowski, Wiktor Wingett, Steven W. Kristina, Tabbada Andrews, Simon Herman, Bram Emily, Leproust Osborne, Cameron S. Koseki, Haruhiko Fraser, Peter Luscombe, Nicholas M. Elderkin, Sarah |
| Abstract | The Polycomb Repressive Complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes1. Emerging evidence suggests that Polycomb complexes act through controlling spatial genome organisation2–9. We show that PRC1 functions as a master regulator of ESC genome architecture by organizing genes in three-dimensional interaction networks. The strongest spatial network is composed of the four Hox clusters and early developmental transcription factor genes, the majority of which contact poised enhancers. Removal of Polycomb repression leads to disruption of promoter-promoter contacts in the Hox network. In contrast, promoter-enhancer contacts are maintained, accompanied by widespread acquisition of active chromatin signatures at network enhancers and pronounced transcriptional up-regulation of network genes. Thus, PRC1 physically constrains developmental transcription factor genes and their enhancers in a silenced but poised spatial network. We propose that selective release of genes from this spatial network underlies cell fate specification during early embryonic development. |
| Related Links | http://dx.doi.org/10.1038/ng.3393 |
| Ending Page | 1186 |
| Page Count | 8 |
| Starting Page | 1179 |
| File Format | |
| ISSN | 10614036 |
| e-ISSN | 15461718 |
| Journal | Nature genetics |
| Issue Number | 10 |
| Volume Number | 47 |
| Language | English |
| Publisher Date | 2015-08-01 |
| Access Restriction | Open |
| Subject Keyword | Genetics Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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