NDLI: G-Protein–Coupled Receptors Signaling Pathways in New Antiplatelet Drug Development

Please wait, while we are loading the content...

Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: Results of 4 Phase III Trials

Cigarette Smoking and Cardiovascular Events: Role of Inflammation and Subclinical Atherosclerosis

Sleep Apnea is Independently Associated with Peripheral Arterial Disease in the Hispanic Community Health Study/Study of Latinos

Year: 2015, Volume: 35, Issue: 2

Year: 2015, Volume: 35, Issue: 1

Year: 2014, Volume: 34

Year: 2013, Volume: 33

Year: 2012, Volume: 32

Year: 2011, Volume: 31

Year: 2010, Volume: 30

Year: 2009, Volume: 29

Year: 2008, Volume: 28

Year: 2007, Volume: 28

Year: 2007, Volume: 27

Year: 2006, Volume: 27

Year: 2006, Volume: 26

Year: 2005, Volume: 25

Year: 2004, Volume: 25

Year: 2004, Volume: 24

Year: 2003, Volume: 23

Year: 2002, Volume: 22

Year: 2001, Volume: 21

Year: 2000, Volume: 20

Year: 1995, Volume: 15

G-Protein–Coupled Receptors Signaling Pathways in New Antiplatelet Drug Development

Content Provider	PubMed Central
Author	Gurbel, Paul A. Athan, Kuliopulos Tantry, Udaya S.
Abstract	Platelet G-protein–coupled receptors influence platelet function by mediating the response to various agonists, including ADP, thromboxane A2, and thrombin. Blockade of the ADP receptor, P2Y12, in combination with cyclooxygenase-1 inhibition by aspirin has been among the most widely used pharmacological strategies to reduce cardiovascular event occurrence in high-risk patients. The latter dual pathway blockade strategy is one of the greatest advances in the field of cardiovascular medicine. In addition to P2Y12, the platelet thrombin receptor, protease activated receptor-1, has also been recently targeted for inhibition. Blockade of protease activated receptor-1 has been associated with reduced thrombotic event occurrence when added to a strategy using P2Y12 and cyclooxygenase-1 inhibition. At this time, the relative contributions of these G-protein–coupled receptor signaling pathways to in vivo thrombosis remain incompletely defined. The observation of treatment failure in ≈10% of high-risk patients treated with aspirin and potent P2Y12 inhibitors provides the rationale for targeting novel pathways mediating platelet function. Targeting intracellular signaling downstream from G-protein–coupled receptor receptors with phosphotidylionisitol 3-kinase and Gq inhibitors are among the novel strategies under investigation to prevent arterial ischemic event occurrence. Greater understanding of the mechanisms of G-protein–coupled receptor–mediated signaling may allow the tailoring of antiplatelet therapy.
Related Links	http://dx.doi.org/10.1161/ATVBAHA.114.303412
Starting Page	500
File Format	PDF
ISSN	15244636
e-ISSN	15244636
Journal	Arteriosclerosis, thrombosis, and vascular biology
Issue Number	3
Volume Number	35
Language	English
Publisher Date	2015-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

G-protein coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases

Role of G-protein coupled receptors in cardiovascular diseases

Conducting the G-protein Coupled Receptor (GPCR) Signaling Symphony in Cardiovascular Diseases: New Therapeutic Approaches

Vascular signaling through G protein coupled receptors - new concepts

Introduction to the Series on Novel Aspects of Cardiovascular G-Protein-Coupled Receptor Signaling

G protein-dependent and –independent signaling pathways and their impact on cardiac function

Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors

G protein-coupled receptors and traditional Chinese medicine: new thinks for the development of traditional Chinese medicine

Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control

G-Protein–Coupled Receptors Signaling Pathways in New Antiplatelet Drug Development

Similar Documents

G-protein coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases

Role of G-protein coupled receptors in cardiovascular diseases

Conducting the G-protein Coupled Receptor (GPCR) Signaling Symphony in Cardiovascular Diseases: New Therapeutic Approaches

Vascular signaling through G protein coupled receptors - new concepts

Introduction to the Series on Novel Aspects of Cardiovascular G-Protein-Coupled Receptor Signaling

G protein-dependent and –independent signaling pathways and their impact on cardiac function

Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors

G protein-coupled receptors and traditional Chinese medicine: new thinks for the development of traditional Chinese medicine

Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control

G-Protein–Coupled Receptors Signaling Pathways in New Antiplatelet Drug Development