NDLI: ERRα Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

Content Provider	PubMed Central
Author	Park, Sunghee Chang, Ching-yi Safi, Rachid Liu, Xiaojing Baldi, Robert Jasper, Jeff S. Anderson, Grace R. Liu, Tingyu Rathmell, Jeffrey C. Dewhirst, Mark W. Wood, Kris C. Locasale, Jason W. Mcdonnell, Donald P.
Abstract	Imaging studies in animals and in humans have indicated that the oxygenation and nutritional status of solid tumors is dynamic. Further, the extremely low level of glucose within tumors, while reflecting its rapid uptake and metabolism, also suggests that cancer cells must rely on other energy sources in some circumstances. Here we find that some breast cancer cells can switch to utilizing lactate as a primary source of energy, allowing them to survive glucose deprivation for extended periods, and that this activity confers resistance to PI3K/mTOR inhibitors. The nuclear receptor, estrogen-related receptor alpha (ERRα), was shown to regulate the expression of genes required for lactate utilization and isotopomer analysis revealed that genetic or pharmacological inhibition of ERRα activity compromised lactate oxidation. Importantly, ERRα antagonists increased the in vitro and in vivo efficacy of PI3K/mTOR inhibitors, highlighting the potential clinical utility of this drug combination.
Related Links	http://dx.doi.org/10.1016/j.celrep.2016.03.026
Ending Page	335
Page Count	13
Starting Page	323
File Format	PDF
ISSN	22111247
e-ISSN	22111247
Journal	Cell reports
Issue Number	2
Volume Number	15
Language	English
Publisher Date	2016-04-12
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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