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| Content Provider | PubMed Central |
|---|---|
| Author | Ugur, Berrak Chen, Kuchuan Bellen, Hugo J. |
| Copyright Year | 2016 |
| Abstract | Many of the internal organ systems of Drosophila melanogaster are functionally analogous to those in vertebrates, including humans. Although humans and flies differ greatly in terms of their gross morphological and cellular features, many of the molecular mechanisms that govern development and drive cellular and physiological processes are conserved between both organisms. The morphological differences are deceiving and have led researchers to undervalue the study of invertebrate organs in unraveling pathogenic mechanisms of diseases. In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. We discuss assays that have been developed in flies to study the function of specific genes in the central nervous system, heart, liver and kidney, and provide examples of the use of these assays to address questions related to human diseases. These assays provide us with simple yet powerful tools to study the pathogenic mechanisms associated with human disease-causing genes. |
| Related Links | http://dx.doi.org/10.1242/dmm.023762 |
| Ending Page | 244 |
| Page Count | 10 |
| Starting Page | 235 |
| File Format | |
| ISSN | 17548403 |
| e-ISSN | 17548411 |
| Journal | Disease Models & Mechanisms |
| Issue Number | 3 |
| Volume Number | 9 |
| Language | English |
| Publisher | The Company of Biologists Ltd |
| Publisher Date | 2016-03-01 |
| Access Restriction | Open |
| Rights Holder | The Company of Biologists Ltd |
| Subject Keyword | Immunology and Microbiology (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) Medicine (miscellaneous) Neuroscience (miscellaneous) Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |
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