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| Content Provider | PubMed Central |
|---|---|
| Author | Li, Yuanyuan Yuan, Xing Shen, Yunheng Zhao, Jing Yue, Rongcai Liu, Fang He, Weiwei Wang, Rui Shan, Lei Zhang, Weidong |
| Copyright Year | 2016 |
| Abstract | Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological systems perspective. We found that BS-I treatment significantly ameliorated learning deficits, improved long-term spatial memory, and reduced plaque load in APP/PS1 mice. We constructed BS-I's therapeutic effect network by mapping the nodes onto the protein-protein interaction (PPI) network constructed according to their functional categories based on genomic and proteomic data. Because many of the top enrichment categories related to the processes of the immune system and phagocytosis were detected, we proposed that BS-I promotes amyloid clearance via the induction of a suitable degree of innate immune stimulation and phagocytosis. Our research may help to clarify the neuroprotective effect of BME and indicated that natural saponins target the immune system, which may offer new research avenues to discover novel treatments for AD. |
| Related Links | http://dx.doi.org/10.18632/aging.100913 |
| Ending Page | 533 |
| Page Count | 13 |
| Starting Page | 521 |
| File Format | |
| ISSN | 19454589 |
| e-ISSN | 19454589 |
| Journal | Aging (Albany NY) |
| Issue Number | 3 |
| Volume Number | 8 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2016-03-01 |
| Access Restriction | Open |
| Rights Holder | Impact Journals LLC |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Aging |
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