NDLI: An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies

Content Provider	PubMed Central
Author	Yuksel, Mustafa Gonul, Suat Banu, Laleci Erturkmen Gokce Anil, Sinaci Ali Invernizzi, Paolo Facchinetti, Sara Migliavacca, Andrea Bergvall, Tomas Kristof, Depraetere Roo, Jos De
Copyright Year	2016
Abstract	Depending mostly on voluntarily sent spontaneous reports, pharmacovigilance studies are hampered by low quantity and quality of patient data. Our objective is to improve postmarket safety studies by enabling safety analysts to seamlessly access a wide range of EHR sources for collecting deidentified medical data sets of selected patient populations and tracing the reported incidents back to original EHRs. We have developed an ontological framework where EHR sources and target clinical research systems can continue using their own local data models, interfaces, and terminology systems, while structural interoperability and Semantic Interoperability are handled through rule-based reasoning on formal representations of different models and terminology systems maintained in the SALUS Semantic Resource Set. SALUS Common Information Model at the core of this set acts as the common mediator. We demonstrate the capabilities of our framework through one of the SALUS safety analysis tools, namely, the Case Series Characterization Tool, which have been deployed on top of regional EHR Data Warehouse of the Lombardy Region containing about 1 billion records from 16 million patients and validated by several pharmacovigilance researchers with real-life cases. The results confirm significant improvements in signal detection and evaluation compared to traditional methods with the missing background information.
Related Links	http://dx.doi.org/10.1155/2016/6741418
Starting Page	6741418
File Format	PDF
ISSN	23146141
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2016
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2016-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems

Using electronic health records for clinical research: the case of the EHR4CR project

GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems

Improving Performance of Clinical Research: Development and Interest of Electronic Health Records

The SMART Platform: early experience enabling substitutable applications for electronic health records

Using Electronic Health Records to Support Clinical Trials: A Report on Stakeholder Engagement for EHR4CR

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies

Similar Documents

GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems

Using electronic health records for clinical research: the case of the EHR4CR project

GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems

Improving Performance of Clinical Research: Development and Interest of Electronic Health Records

The SMART Platform: early experience enabling substitutable applications for electronic health records

Using Electronic Health Records to Support Clinical Trials: A Report on Stakeholder Engagement for EHR4CR

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies