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| Content Provider | PubMed Central |
|---|---|
| Author | Lee, Yi-ying Wu, Wen-jeng Huang, Chun-nung Li, Ching-chia Li, Wei-ming Yeh, Bi-wen Liang, Peir-in Wu, Ting-feng Li, Chien-feng |
| Copyright Year | 2016 |
| Abstract | Background: Urothelial carcinoma (UC) commonly occurs in the urinary bladder (UB) and rarely in upper the upper urinary tract (UT). Its molecular pathogenesis, however, remains obscure. Though the constitutive phosphorylation of Signal Transducer and Activator of Transcription 5 (STAT5) is an important part of carcinogenesis generally, researchers have not systematically investigated this process specifically in relation to UC. The present study addresses this gap. Through data mining a published transcriptomic database of UBUCs (GSE32894), it identified Colony Stimulating Factor 2 (CSF2) as the stepwise upregulated gene of much significance among those related to the positive regulation of tyrosine phosphorylation of STAT5 (GO:0042523). Since the phosphorylation of STAT5, a key process in the development of UC, is closely associated with CSF2, we then examine CSF2 transcript and protein expression, justifying their association with clinicopathological features and survival in our well-established cohort of patients with UC. |
| Related Links | http://dx.doi.org/10.7150/jca.14281 |
| Ending Page | 721 |
| Page Count | 11 |
| Starting Page | 711 |
| File Format | |
| ISSN | 18379664 |
| e-ISSN | 18379664 |
| Journal | Journal of Cancer |
| Issue Number | 6 |
| Volume Number | 7 |
| Language | English |
| Publisher | Ivyspring International Publisher |
| Publisher Date | 2016-03-26 |
| Access Restriction | Open |
| Rights Holder | Ivyspring International Publisher |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
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