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| Content Provider | PubMed Central |
|---|---|
| Author | Miano, Valentina Ferrero, Giulio Reineri, Stefania Caizzi, Livia Laura, Annaratone Ricci, Laura Cutrupi, Santina Castellano, Isabella Cordero, Francesca Bortoli, Michele De |
| Copyright Year | 2016 |
| Abstract | Estrogen Receptor alpha (ERα) activation by estrogenic hormones induces luminal breast cancer cell proliferation. However, ERα plays also important hormone-independent functions to maintain breast tumor cells epithelial phenotype. We reported previously by RNA-Seq that in MCF-7 cells in absence of hormones ERα down-regulation changes the expression of several genes linked to cellular development, representing a specific subset of estrogen-induced genes. Here, we report regulation of long non-coding RNAs from the same experimental settings. A list of 133 Apo-ERα-Regulated lncRNAs (AER-lncRNAs) was identified and extensively characterized using published data from cancer cell lines and tumor tissues, or experiments on MCF-7 cells. For several features, we ran validation using cell cultures or fresh tumor biopsies. AER-lncRNAs represent a specific subset, only marginally overlapping estrogen-induced transcripts, whose expression is largely restricted to luminal cells and which is able to perfectly classify breast tumor subtypes. The most abundant AER-lncRNA, DSCAM-AS1, is expressed in ERα+ breast carcinoma, but not in pre-neoplastic lesions, and correlates inversely with EMT markers. Down-regulation of DSCAM-AS1 recapitulated, in part, the effect of silencing ERα, i.e. growth arrest and induction of EMT markers. In conclusion, we report an ERα-dependent lncRNA set representing a novel luminal signature in breast cancer cells. |
| Related Links | http://dx.doi.org/10.18632/oncotarget.6420 |
| Starting Page | 3201 |
| File Format | |
| ISSN | 19492553 |
| e-ISSN | 19492553 |
| Journal | Oncotarget |
| Issue Number | 3 |
| Volume Number | 7 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Rights Holder | Impact Journals LLC |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
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