NDLI: Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1993, Volume: 90, Issue: 24

Testosterone in egg yolks: an ornithologist's perspective.

Cellular signaling: new insights into the action of the plant growth hormone auxin.

Yolk is a source of maternal testosterone for developing birds.

Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system.

Structurally engineered cytochromes with unusual ligand-binding properties: expression of Saccharomyces cerevisiae Met-80-->Ala iso-1-cytochrome c.

Strings of contiguous modified pentanucleotides with increased DNA-binding affinity can be used for DNA sequencing by primer walking.

Transmembrane neural cell-adhesion molecule (NCAM), but not glycosyl-phosphatidylinositol-anchored NCAM, down-regulates secretion of matrix metalloproteinases.

Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.

Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine.

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

Modulation of K+ channels in Vicia stomatal guard cells by peptide homologs to the auxin-binding protein C terminus.

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.

V3 variability can influence the ability of an antibody to neutralize or enhance infection by diverse strains of human immunodeficiency virus type 1.

In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2.

The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C.

Translation of the human LINE-1 element, L1Hs.

Site-specific cleavage and joining of single-stranded DNA by VirD2 protein of Agrobacterium tumefaciens Ti plasmids: analogy to bacterial conjugation.

Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases.

Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex.

Animals and fungi are each other's closest relatives: congruent evidence from multiple proteins.

BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element.

Transcriptional regulation of HLA-A and -B: differential binding of members of the Rel and IRF families of transcription factors.

Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture.

Synaptic inhibition regulates associative interactions between afferents during the induction of long-term potentiation and depression.

DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.

Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells.

Induction of erythroid-specific gene expression in lymphoid cells.

Localization of the colchicine-binding site of tubulin.

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism.

The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.

Osteoporosis induced in mice by overproduction of interleukin 4.

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen.

Rapid solution assays for retroviral integration reactions and their use in kinetic analyses of wild-type and mutant Rous sarcoma virus integrases.

Catalytic contribution of flap-substrate hydrogen bonds in "HIV-1 protease" explored by chemical synthesis.

Cys4057 of apolipoprotein(a) is essential for lipoprotein(a) assembly.

Val-->Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein.

Kinesin swivels to permit microtubule movement in any direction.

Evidence that facilitative glucose transporters may fold as beta-barrels.

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

A fourth class of theta-replicating plasmids: the pAM beta 1 family from gram-positive bacteria.

Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.

Enhancer activity of light-responsive regulatory elements in the untranslated leader regions of cyanobacterial psbA genes.

Active immunity against the CD4 receptor by using an antibody antigenized with residues 41-55 of the first extracellular domain.

Functional kainate-selective glutamate receptors in cultured hippocampal neurons.

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Pulse mass measles vaccination across age cohorts.

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.

Multiple motifs regulate the B-cell-specific promoter of the B29 gene.

Mevalonate availability and cardiovascular functions.

A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection.

Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.

IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer.

Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.

Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.

The accessory bacteriochlorophyll: a real electron carrier in primary photosynthesis.

The first step in vision occurs in femtoseconds: complete blue and red spectral studies.

A large cell-adhesive scatter factor secreted by human gastric carcinoma cells.

Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor.

Evolution and expression of a beta-like globin gene of the Australian marsupial Sminthopsis crassicaudata.

PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae.

Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells.

Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.

Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.

Zinc modulation of a transient potassium current and histochemical localization of the metal in neurons of the suprachiasmatic nucleus.

The effect of sequences with high AU content on mRNA stability in tobacco.

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.

Primer-mediated in situ detection of the B-hordein gene cluster on barley chromosome 1H.

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Metabolic correction and cross-correction of mucopolysaccharidosis type II (Hunter syndrome) by retroviral-mediated gene transfer and expression of human iduronate-2-sulfatase.

Acyclovir diphosphate dimyristoylglycerol: a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus.

A gene encoding a protein related to eukaryotic protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120.

The presequence of Euglena LHCPII, a cytoplasmically synthesized chloroplast protein, contains a functional endoplasmic reticulum-targeting domain.

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A.

Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.

Fast events in protein folding initiated by nanosecond laser photolysis.

The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry.

Genes in one megabase of the HLA class I region.

The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.

Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation.

Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.

Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line.

A masculinizing effect on the auditory systems of human females having male co-twins.

Interleukin 6 inhibits mouse placental lactogen II but not mouse placental lactogen I secretion in vitro.

Antibody-catalyzed reversal of chemoselectivity.

Equilibration during mantle melting: a fractal tree model.

Mutational analysis of the helper component-proteinase gene of a potyvirus: effects of amino acid substitutions, deletions, and gene replacement on virulence and aphid transmissibility.

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

Correlations between isochores and chromosomal bands in the human genome.

A neo-Darwinian algorithm: asymmetrical mutations due to semiconservative DNA-type replication promote evolution.

Biotinylated diaminopyridine: an approach to tagging oligosaccharides and exploring their biology.

Mathematical textbook of deformable neuroanatomies.

Immunocytochemical localization of the plasma membrane calcium pump, calbindin-D28k, and parvalbumin in Purkinje cells of avian and mammalian cerebellum.

Signal efficacy and the evolution of male dimorphism in the jumping spider, Maevia inclemens.

Distortion of area and dimension under quasiconformal mappings in the plane.

Transcriptional regulatory elements downstream of the JunB gene.

Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease.

Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.

Eukaryotic cytosolic chaperonin contains t-complex polypeptide 1 and seven related subunits.

Aspartate transcarbamoylase containing circularly permuted catalytic polypeptide chains.

Two functionally distinct forms of the photosystem II reaction-center protein D1 in the cyanobacterium Synechococcus sp. PCC 7942.

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity.

Number of CpG islands and genes in human and mouse.

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

Allele-specific peptide ligand motifs of HLA-C molecules.

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.

Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.

Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum.

Deficient transcription of XIST from tiny ring X chromosomes in females with severe phenotypes.

The gene responsible for Werner syndrome may be a cell division "counting" gene.

Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes.

In vivo protection against endotoxin by plasma high density lipoprotein.

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

Protein kinase C and F1/GAP-43 gene expression in hippocampus inversely related to synaptic enhancement lasting 3 days.

Molecular cloning of the gene for the allatostatin family of neuropeptides from the cockroach Diploptera punctata

Recombinant human migration inhibitory factor has adjuvant activity

Synthetic peptides based upon a three-dimensional model for the receptor recognition site of follicle-stimulating hormone exhibit antagonistic or agonistic activity at low concentrations

tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system

Year: 1993, Volume: 90, Issue: 23

Year: 1993, Volume: 90, Issue: 22

Year: 1993, Volume: 90, Issue: 21

Year: 1993, Volume: 90, Issue: 20

Year: 1993, Volume: 90, Issue: 19

Year: 1993, Volume: 90, Issue: 18

Year: 1993, Volume: 90, Issue: 17

Year: 1993, Volume: 90, Issue: 16

Year: 1993, Volume: 90, Issue: 15

Year: 1993, Volume: 90, Issue: 14

Year: 1993, Volume: 90, Issue: 13

Year: 1993, Volume: 90, Issue: 12

Year: 1993, Volume: 90, Issue: 11

Year: 1993, Volume: 90, Issue: 10

Year: 1993, Volume: 90, Issue: 9

Year: 1993, Volume: 90, Issue: 8

Year: 1993, Volume: 90, Issue: 7

Year: 1993, Volume: 90, Issue: 6

Year: 1993, Volume: 90, Issue: 5

Year: 1993, Volume: 90, Issue: 4

Year: 1993, Volume: 90, Issue: 3

Year: 1993, Volume: 90, Issue: 2

Year: 1993, Volume: 90, Issue: 1

Year: 1992, Volume: 89

Year: 1991, Volume: 88

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.

Content Provider	PubMed Central
Author	Thibault, O. Porter, N. M. Landfield, P. W.
Abstract	Openings of single L-type Ca2+ channels following repolarization to negative membrane potentials from a depolarizing step (repolarization openings, ROs) have been described previously in brain cell preparations. However, these ROs have been reported to occur only infrequently. Here we report that the frequency of ROs in cell-attached patches of cultured rat hippocampal neurons can be increased dramatically by lowering the pipette Ba2+ concentration to 20 mM from the usual 90-110 mM. This increased opening probability can last for hundreds to thousands of milliseconds following repolarization. Current-voltage analyses of open probability show that the depolarization pulse threshold for inducing ROs in 20 mM Ba2+ is -10 to 0 mV but that the probability of ROs reaches maximal levels following depolarizing pulses that approach the apparent null (equilibrium) potential for Ba2+. Comparable current-voltage curves in 110 mM Ba2+ from a more positive holding potential (-50 mV) indicate that membrane surface charge screening accounts for some, but not all, of the effect of lowering the Ba2+ concentration. Consequently, current-dependent inactivation or some other ion-dependent mechanism (e.g., ion binding inside the pore) also appears to regulate this potentially major pathway of Ca2+ entry. A high probability of ROs also can be induced under relatively physiological conditions (5-ms depolarizing steps, 2-5 mM Ca2+ in the pipette). Thus, the high open probability state at negative potentials may underlie the long Ca2+ tail currents in hippocampus that were described previously and appears to have major implications for physiological functions (e.g., the slow Ca(2+)-dependent afterhyperpolarization), particularly in brain neurons.
Starting Page	11792
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	90
Language	English
Publisher Date	1993-12-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in