NDLI: In Vivo Models for Incretin Research: From the Intestine to the Whole Body

Content Provider	PubMed Central
Author	Oh, Tae Jung
Copyright Year	2016
Abstract	Incretin hormones are produced by enteroendocrine cells (EECs) in the intestine in response to ingested nutrient stimuli. The incretin effect is defined as the difference in the insulin secretory response between the oral glucose tolerance test and an isoglycemic intravenous glucose infusion study. The pathophysiology of the decreased incretin effect has been studied as decreased incretin sensitivity and/or β-cell dysfunction per se. Interestingly, robust increases in endogenous incretin secretion have been observed in many types of metabolic/bariatric surgery. Therefore, metabolic/bariatric surgery has been extensively studied for incretin physiology, not only the hormones themselves but also alterations in EECs distribution and genetic expression levels of gut hormones. These efforts have given us an enormous understanding of incretin biology from synthesis to in vivo behavior. Further innovative studies are needed to determine the mechanisms and targets of incretin hormones.
Related Links	http://dx.doi.org/10.3803/enm.2016.31.1.45
Starting Page	45
File Format	PDF
ISSN	2093596X
e-ISSN	20935978
Journal	Endocrinology and Metabolism
Issue Number	1
Volume Number	31
Language	English
Publisher	Korean Endocrine Society
Publisher Date	2016-01-01
Access Restriction	Open
Rights Holder	Korean Endocrine Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology

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