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| Content Provider | PubMed Central |
|---|---|
| Author | Osamor, Victor Chukwudi Chinedu, Shalom N. Azuh, Dominic E. Iweala, Emeka Joshua Ogunlana, Olubanke Olujoke |
| Copyright Year | 2016 |
| Abstract | Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on whether histone marks are read, added, or removed, respectively, from a specific amino acid. Transcription is controlled by dynamic epigenetic marks with serious health implications in certain complex diseases, whose understanding may be useful in gene therapy. This work highlights traditional and current advances in post-translational modifications with relevance to gene therapy delivery. We report that enhanced understanding of epigenetic machinery provides clues to functional implication of certain genes/gene products and may facilitate transition toward revision of our clinical treatment procedure with effective fortification of gene therapy delivery. |
| Related Links | http://dx.doi.org/10.2147/DDDT.S80496 |
| Ending Page | 871 |
| Page Count | 11 |
| Starting Page | 861 |
| File Format | |
| ISSN | 11778881 |
| e-ISSN | 11778881 |
| Journal | Drug Design, Development and Therapy |
| Volume Number | 10 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2016-02-29 |
| Access Restriction | Open |
| Rights Holder | Dove Medical Press |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology Pharmaceutical Science |
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