NDLI: Surface coating affects behavior of metallic nanoparticles in a biological environment

Content Provider	PubMed Central
Author	Jurašin, Darija Domazet Ćurlin, Marija Capjak, Ivona Crnković, Tea Marija, Lovrić Michal, Babič Horák, Daniel Ivana, Vinković Vrček Gajović, Srećko
Editor	Stenzel, Martina
Copyright Year	2016
Abstract	Silver (AgNPs) and maghemite, i.e., superparamagnetic iron oxide nanoparticles (SPIONs) are promising candidates for new medical applications, which implies the need for strict information regarding their physicochemical characteristics and behavior in a biological environment. The currently developed AgNPs and SPIONs encompass a myriad of sizes and surface coatings, which affect NPs properties and may improve their biocompatibility. This study is aimed to evaluate the effects of surface coating on colloidal stability and behavior of AgNPs and SPIONs in modelled biological environments using dynamic and electrophoretic light scattering techniques, as well as transmission electron microscopy to visualize the behavior of the NP. Three dispersion media were investigated: ultrapure water (UW), biological cell culture medium without addition of protein (BM), and BM supplemented with common serum protein (BMP). The obtained results showed that different coating agents on AgNPs and SPIONs produced different stabilities in the same biological media. The combination of negative charge and high adsorption strength of coating agents proved to be important for achieving good stability of metallic NPs in electrolyte-rich fluids. Most importantly, the presence of proteins provided colloidal stabilization to metallic NPs in biological fluids regardless of their chemical composition, surface structure and surface charge. In addition, an assessment of AgNP and SPION behavior in real biological fluids, rat whole blood (WhBl) and blood plasma (BlPl), revealed that the composition of a biological medium is crucial for the colloidal stability and type of metallic NP transformation. Our results highlight the importance of physicochemical characterization and stability evaluation of metallic NPs in a variety of biological systems including as many NP properties as possible.
Related Links	http://dx.doi.org/10.3762/bjnano.7.23
Ending Page	262
Page Count	17
Starting Page	246
File Format	PDF
ISSN	21904286
e-ISSN	21904286
Journal	Beilstein Journal of Nanotechnology
Volume Number	7
Language	English
Publisher	Beilstein-Institut
Publisher Date	2016-02-01
Access Restriction	Open
Rights Holder	Beilstein-Institut
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Physics and Astronomy Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ultrafine metallic Fe nanoparticles: synthesis, structure and magnetism

Green and energy-efficient methods for the production of metallic nanoparticles

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

Friction behavior of a microstructured polymer surface inspired by snake skin

Size-dependent phase diagrams of metallic alloys: A Monte Carlo simulation study on order–disorder transitions in Pt–Rh nanoparticles

Synthesis of LiNbO3 nanoparticles in a mesoporous matrix

Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

Controlled positioning of nanoparticles on a micrometer scale

Surface coating affects behavior of metallic nanoparticles in a biological environment

Similar Documents

Ultrafine metallic Fe nanoparticles: synthesis, structure and magnetism

Green and energy-efficient methods for the production of metallic nanoparticles

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

Friction behavior of a microstructured polymer surface inspired by snake skin

Size-dependent phase diagrams of metallic alloys: A Monte Carlo simulation study on order–disorder transitions in Pt–Rh nanoparticles

Synthesis of LiNbO3 nanoparticles in a mesoporous matrix

Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

Controlled positioning of nanoparticles on a micrometer scale

Surface coating affects behavior of metallic nanoparticles in a biological environment