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| Content Provider | PubMed Central |
|---|---|
| Author | Kuniaki, Aridome Mori, Shin-ichirou Baba, Kenji Yanagi, Masayuki Masahiro, Hamanoue Miyazono, Futoshi Tokuda, Kouki Imamura, Hiroshi Ogura, Yoshito Kaneko, Kouichi Kijima, Fumio Kousei, Maemura Ishigami, Sumiya Shoji, Natsugoe |
| Copyright Year | 2016 |
| Abstract | The present study aimed to study the efficacy of aprepitant in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy (MEC) for colorectal cancer (CRC), and comprised a multicenter, phase II, open-label, randomized, parallel comparative study conducted as part of the Kagoshima aprepitant study for colon cancer in Japan. Patients with advanced or recurrent CRC were treated with standard MEC regimens (FOLFOX, XELOX or FOLFIRI) and received either standard chemotherapy [5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) + dexamethasone] or aprepitant regimen chemotherapy (5-HT3 RA + reduced-dose dexamethasone + aprepitant). The primary endpoint of the present study was the proportion of patients who achieved a complete response (CR) during the overall, acute, and delayed phases of the first planned chemotherapy cycle. Secondary endpoints were complete protection, the proportions of patients without emetic episodes or nausea, patients with no more than moderate nausea during the overall, acute and delayed phases, and the time to treatment failure. The CR rates in the overall, acute and delayed phases were similar in the aprepitant and the standard-regimen groups. Additionally, there were no significant differences in secondary endpoints between the two groups. In summary, aprepitant in combination with 5-HT3 RA and reduced-dose corticosteroids was well tolerated and effective in preventing CINV associated with moderately emetogenic antitumor agents in Japanese patients with CRC. |
| Related Links | http://dx.doi.org/10.3892/mco.2015.724 |
| Starting Page | 393 |
| File Format | |
| ISSN | 20499450 |
| e-ISSN | 20499469 |
| Journal | Molecular and Clinical Oncology |
| Issue Number | 3 |
| Volume Number | 4 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2015-12-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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