NDLI: The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men

Content Provider	PubMed Central
Author	Liu, Ming Shi, Xiaohong Yang, Fan Wang, Jianye Xu, Yong Wei, Dong Yang, Kuo Zhang, Yaoguang Wang, Xin Liang, Siying Chen, Xin Sun, Liang Zhu, Xiaoquan Zhao, Chengxiao Zhu, Ling Tang, Lei Zheng, Chenguang Yang, Ze
Editor	Tchounwou, Paul B.
Copyright Year	2016
Abstract	Prostate cancer (PCa) is a multifactorial disease involving complex genetic and environmental factors interactions. Gene-gene and gene-environment interactions associated with PCa in Chinese men are less studied. We explored the association between 36 SNPs and PCa in 574 subjects from northern China. Body mass index (BMI), smoking, and alcohol consumption were determined through self-administered questionnaires in 134 PCa patients. Then gene-gene and gene-environment interactions among the PCa-associated SNPs were analyzed using the generalized multifactor dimensionality reduction (GMDR) and logistic regression methods. Allelic and genotypic association analyses showed that six variants were associated with PCa and the cumulative effect suggested men who carried any combination of 1, 2, or ≥3 risk genotypes had a gradually increased PCa risk (odds ratios (ORs) = 1.79–4.41). GMDR analysis identified the best gene-gene interaction model with scores of 10 for both the cross-validation consistency and sign tests. For gene-environment interactions, rs6983561 CC and rs16901966 GG in individuals with a BMI ≥ 28 had ORs of 7.66 (p = 0.032) and 5.33 (p = 0.046), respectively. rs7679673 CC + CA and rs12653946 TT in individuals that smoked had ORs of 2.77 (p = 0.007) and 3.11 (p = 0.024), respectively. rs7679673 CC in individuals that consumed alcohol had an OR of 4.37 (p = 0.041). These results suggest that polymorphisms, either individually or by interacting with other genes or environmental factors, contribute to an increased risk of PCa.
Related Links	http://dx.doi.org/10.3390/ijerph13020162
Starting Page	162
File Format	PDF
ISSN	16604601
e-ISSN	16604601
Journal	International Journal of Environmental Research and Public Health
Issue Number	2
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2016-01-01
Access Restriction	Open
Rights Holder	MDPI
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Pollution Public Health, Environmental and Occupational Health

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