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| Content Provider | PubMed Central |
|---|---|
| Author | Seong-ho, Ok Kim, Won Ho Yu, Jongsun Lee, Youngju Choi, Mun-jeoung Lim, Dong Hoon Hwang, Yeran Kim, Yeon A. Sohn, Ju-tae |
| Copyright Year | 2016 |
| Abstract | The goal of this in vitro study was to examine the effects of pre-acidification and pre-akalinization on the lipid emulsion-mediated reversal of toxic dose levobupivacaine-induced vasodilation in isolated rat aorta. Isolated aortic rings with and without the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) were exposed to four types of Krebs solution (pH 7.0, 7.2, 7.4, and 7.6), followed by the addition of 60 mM potassium chloride. When the toxic dose of levobupivacaine (3 × 10-4 M) produced a stable and sustained vasodilation in the isolated aortic rings that were precontracted with 60 mM potassium chloride, increasing lipid emulsion concentrations (SMOFlipid®: 0.24, 0.48, 0.95 and 1.39%) were added to generate concentration-response curves. The effects of mild pre-acidification alone and mild pre-acidification in combination with a lipid emulsion on endothelial nitric oxide synthase (eNOS) phosphorylation in human umbilical vein endothelial cells were investigated by Western blotting. Mild pre-acidification caused by the pH 7.2 Krebs solution enhanced the lipid emulsion-mediated reversal of levobupivacaine-induced vasodilation in isolated endothelium-intact aortic rings, whereas mild pre-acidification caused by the pH 7.2 Krebs solution did not significantly alter the lipid emulsion-mediated reversal of the levobupivacaine-induced vasodilation in isolated endothelium-denuded aortic rings or endothelium-intact aortic rings with L-NAME. A lipid emulsion attenuated the increased eNOS phosphorylation induced by the pH 7.2 Krebs solution. Taken together, these results suggest that mild pre-acidification enhances the lipid emulsion-mediated reversal of toxic dose levobupivacaine-induced vasodilation in the endothelium-intact aorta via the inhibition of nitric oxide. |
| Related Links | http://dx.doi.org/10.7150/ijms.13016 |
| Ending Page | 76 |
| Page Count | 9 |
| Starting Page | 68 |
| File Format | |
| ISSN | 14491907 |
| e-ISSN | 14491907 |
| Journal | International Journal of Medical Sciences |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Ivyspring International Publisher |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Rights Holder | Ivyspring International Publisher |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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