NDLI: Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components

Content Provider	PubMed Central
Author	Liu, Rongrong Truax, Agnieszka D. Chen, Liang Hu, Peizhen Li, Zengshan Chen, Jun Song, Chaojun Chen, Lihua Ting, Jenny Pan-yun
Copyright Year	2015
Abstract	NLRs (nucleotide-binding domain leucine-rich repeat proteins or NOD-like receptors) are regulators of inflammation and immunity. A subgroup of NLRs and the innate immune receptor, AIM2 (absent-in-melanoma 2), can induce the assembly of a large caspase-1 activating complex called the inflammasome. Other NLRs regulate key signaling pathways such as NF-kB and MAPK. Since inflammation is a central component of colorectal cancer (CRC), this work was undertaken to analyze NLR and AIM2 expression in human CRC by combining bioinformatics analysis and experimental verification using clinical tissue samples. Additional experiments analyzed the association of (i) gene expression and cancer staging, and (ii) gene expression among inflammasome components.
Related Links	http://dx.doi.org/10.18632/oncotarget.5587
Ending Page	33469
Page Count	14
Starting Page	33456
File Format	PDF
ISSN	19492553
e-ISSN	19492553
Journal	Oncotarget
Issue Number	32
Volume Number	6
Language	English
Publisher	Impact Journals LLC
Publisher Date	2015-10-01
Access Restriction	Open
Rights Holder	Impact Journals LLC
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Oncology

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Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components