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| Content Provider | PubMed Central |
|---|---|
| Author | Huang, Weina Lin, Jie Zhang, Hongxuan |
| Copyright Year | 2016 |
| Abstract | Colon cancer is one of the most common, lethal diseases worldwide. Tumor metastasis and chemotherapy resistance are the main reasons for its poor prognosis and high fatality rate. Tumor development is thought of as one of the most complex cellular events as it is a multi-step cascading process involving infinite proliferation, invasion and immigration. Recently, increasing studies have demonstrated that microRNA-126 (miR-126) has an important role in colon cancer. The expression of miR-126 decreased significantly in colon cancer, particularly in highly metastatic cell lines. miR-126 controls tumor cell growth, metastasis and survival via inactivation of the oncogene signaling pathway, indicating that miR-126 may serve as a therapeutic target for anticancer therapy. Potentially, miR-126 was also reported to be an ideal molecular target as a novel biomarker for liver metastasis from colorectal cancer due to its changeable expression level. In the present review, the current knowledge regarding regulatory function of miR-126 is summarized along with its underlying mechanisms in colon cancer. |
| Related Links | http://dx.doi.org/10.3892/br.2015.549 |
| Ending Page | 134 |
| Page Count | 4 |
| Starting Page | 131 |
| File Format | |
| ISSN | 20499442 |
| e-ISSN | 20499442 |
| Journal | Biomedical Reports |
| Issue Number | 2 |
| Volume Number | 4 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2016-02-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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