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| Content Provider | PubMed Central |
|---|---|
| Author | Akil, Hussein Perraud, Aurélie Jauberteau, Marie-odile Muriel, Mathonnet |
| Copyright Year | 2016 |
| Abstract | Colorectal cancer (CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients’ long-term survival. Several tyrosine kinase receptors have been implicated in CRC development, progression and metastasis, including epidermal growth factor receptor (EGFR) and vascular EGFR. Recently, tropomyosin-related kinase B (TrkB), a tyrosine kinase receptor, has been reported in CRC and found to clearly exert several biological and clinical features, such as tumor cell growth and survival in vitro and in vivo, metastasis formation and poor prognosis. Here we review the significance of TrkB and its ligand brain derived-neurotrophic factor in CRC. We focus on their expression in CRC tumor samples, and their functional roles in CRC cell lines and in in vivo models. Finally we discuss therapeutic approaches that can lead to the development of novel therapeutic agents for treating TrkB-expressing CRC tumors. |
| Related Links | http://dx.doi.org/10.3748/wjg.v22.i2.490 |
| Starting Page | 490 |
| File Format | |
| ISSN | 10079327 |
| e-ISSN | 22192840 |
| Journal | World Journal of Gastroenterology |
| Issue Number | 2 |
| Volume Number | 22 |
| Language | English |
| Publisher | Baishideng Publishing Group Inc |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Rights Holder | Baishideng Publishing Group Inc |
| Subject Keyword | Gastroenterology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
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