NDLI: Adjuvant radiochemotherapy for gastric cancer: Should we use prognostic factors to select patients?

Content Provider	PubMed Central
Author	Agolli, Linda Enrici, Riccardo Maurizi Osti, Mattia Falchetto
Copyright Year	2016
Abstract	Radiotherapy has a not well-established role in the pre-operative and in the post-operative setting in gastric cancer (GC) patients. Randomized trials report controversial outcomes and impact on survival. In the D2 loco-regional node resection era, after a well-performed radical surgery, local treatment using radiotherapy combined to chemotherapy should be considered for locally advanced GC. Prognostic factors could help the better selection of subgroups that present high risk of loco-regional recurrence. Then, the addition of radiotherapy could improve the disease-free survival and also quality of life. There are no large prospective studies that have assessed specific factors predicting for recurrence or survival, but only retrospective series, some of them including high number of patients with homogeneous characteristics. In locally advanced GC adding radiotherapy to the post-operative chemotherapy seems to improve outcomes and quality of life. Prognostic factors such as T-stage, N-status, nodal ratio, and other histological factors should be considered to submit patients to post-operative combined treatment. Larger prospective series are necessary to investigate the role of combined chemoradiation after radical D2-resection, especially in locally advanced GC. Further prospective investigations are needed to suggest prognostic factors that have significant impact on survival and recurrence, improving the management and outcomes, particularly in locally advanced GC patients.
Related Links	http://dx.doi.org/10.3748/wjg.v22.i3.1131
Ending Page	1138
Page Count	8
Starting Page	1131
File Format	PDF
ISSN	22192840
e-ISSN	22192840
Journal	World Journal of Gastroenterology
Issue Number	3
Volume Number	22
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2016-01-21
Access Restriction	Open
Rights Holder	Baishideng Publishing Group Inc
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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