WebSite Logo
  • Content
  • Similar Resources
  • Metadata
  • Cite This
  • Language
    অসমীয়া বাংলা भोजपुरी डोगरी English ગુજરાતી हिंदी ಕನ್ನಡ
    Khasi कोंकणी मैथिली മലയാളം ꯃꯤꯇꯩ ꯂꯣꯟ मराठी Mizo नेपाली
    ଓଡ଼ିଆ ਪੰਜਾਬੀ संस्कृत ᱥᱟᱱᱛᱟᱲᱤ सिन्धी தமிழ் తెలుగు اردو
  • Log-in
  • Fullscreen
Log-in
Do not have an account? Register Now
Forgot your password? Account recovery
  1. Fungal genetics and biology : FG & B
  2. Year: 2015, Volume: 75
  3. Year: 2015, Volume: 75, Issue: Unspecified
  4. Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
Loading...

Please wait, while we are loading the content...

Year: 2016, Volume: 87
Year: 2015, Volume: 79
Year: 2015, Volume: 78
Year: 2015, Volume: 76
Year: 2015, Volume: 75
Year: 2015, Volume: 75, Issue: Unspecified
Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
Next Generation Multilocus Sequence Typing (NGMLST) and the Analytical Software Program MLSTEZ Enable Efficient, Cost-Effective, High-Throughput, Multilocus Sequencing Typing
Year: 2015, Volume: 74
Year: 2014, Volume: 73
Year: 2014, Volume: 72
Year: 2014, Volume: 70
Year: 2014, Volume: 69
Year: 2014, Volume: 66
Year: 2013, Volume: 60
Year: 2013, Volume: 57
Year: 2013, Volume: 50
Year: 2013, Volume: 0
Year: 2012, Volume: 49
Year: 2011, Volume: 48
Year: 2010, Volume: 47
Year: 2009, Volume: 46
Year: 2008, Volume: 45
Year: 2007, Volume: 44

Similar Documents

...
The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence

Article

...
Role of Ferroxidases in Iron Uptake and Virulence of Cryptococcus neoformans ▿ †

Article

...
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.

Article

...
Factors Required for Activation of Urease as a Virulence Determinant in Cryptococcus neoformans

Article

...
Wsp1, a GBD/CRIB Domain-Containing WASP Homolog, Is Required for Growth, Morphogenesis, and Virulence of Cryptococcus neoformans ▿ †

Article

...
Cryptococcus neoformans Yap1 is required for normal fluconazole and oxidative stress resistance

Article

...
Cryptococcus neoformans Mediator Protein Ssn8 Negatively Regulates Diverse Physiological Processes and Is Required for Virulence

Article

...
A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans

Article

...
“Virulence Mechanisms and Cryptococcus neoformans pathogenesis”

Article

Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans

Content Provider PubMed Central
Author Do, Eunsoo Hu, Guanggan Caza, Mélissa Oliveira, Debora Kronstad, James W. Jung, Won Hee
Abstract Amino acid biosynthetic pathways that are absent in mammals are considered an attractive target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of a five-step conversion process starting from the valine precursor 2-keto-isovalerate. Isopropylmalate dehydrogenase (Leu1) is an Fe-S cluster protein that is required for leucine biosynthesis in the model fungus Saccharomyces cerevisiae. The human pathogenic fungus Cryptococcus neoformans possesses an ortholog of S. cerevisiae Leu1, and our previous transcriptome data showed that the expression of LEU1 is regulated by iron availability. In this study, we characterized the role of Leu1 in iron homeostasis and the virulence of C. neoformans. We found that deletion of LEU1 caused leucine auxotrophy and that Leu1 may play a role in the mitochondrial-cytoplasmic Fe-S cluster balance. Whereas cytoplasmic Fe-S protein levels were not affected, mitochondrial Fe-S proteins were up- regulated in the leu1 mutant, suggesting that Leu1 mainly influences mitochondrial iron metabolism. The leu1 mutant also displayed increased sensitivity to oxidative stress and cell wall/membrane disrupting agents, which may have been caused by mitochondrial dysfunction. Furthermore, the leu1 mutant was deficient in capsule formation and showed attenuated virulence in a mouse inhalation model of cryptococcosis. Overall, our results indicate that Leu1 plays a role in iron metabolism and is required for virulence in C. neoformans.
Related Links http://dx.doi.org/10.1016/j.fgb.2014.12.006
Ending Page 19
Page Count 9
Starting Page 11
File Format PDF
ISSN 10960937
e-ISSN 10960937
Journal Fungal genetics and biology : FG & B
Volume Number 75
Language English
Publisher Date 2015-02-01
Access Restriction Open
Subject Keyword Research in Higher Education
Content Type Text
Resource Type Article
Subject Genetics Microbiology
  • About
  • Disclaimer
  • Feedback
  • Sponsor
  • Contact
About National Digital Library of India (NDLI)
NDLI logo

National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.

Learn more about this project from here.

Disclaimer

NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.

Feedback

Sponsor

Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.

Contact National Digital Library of India
Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302
See location in the Map
03222 282435
Mail: support@ndl.gov.in
Sl. Authority Responsibilities Communication Details
1 Ministry of Education (GoI),
Department of Higher Education
Sanctioning Authority https://www.education.gov.in/ict-initiatives
2 Indian Institute of Technology Kharagpur Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project https://www.iitkgp.ac.in
3 National Digital Library of India Office, Indian Institute of Technology Kharagpur The administrative and infrastructural headquarters of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
4 Project PI / Joint PI Principal Investigator and Joint Principal Investigators of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
Prof. Saswat Chakrabarti  will be added soon
5 Website/Portal (Helpdesk) Queries regarding NDLI and its services support@ndl.gov.in
6 Contents and Copyright Issues Queries related to content curation and copyright issues content@ndl.gov.in
7 National Digital Library of India Club (NDLI Club) Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach clubsupport@ndl.gov.in
8 Digital Preservation Centre (DPC) Assistance with digitizing and archiving copyright-free printed books dpc@ndl.gov.in
9 IDR Setup or Support Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops idr@ndl.gov.in
Cite this Content
Loading...