NDLI: Diazepam dependence prevented by glutamate antagonists.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1993, Volume: 90, Issue: 24

Year: 1993, Volume: 90, Issue: 23

Year: 1993, Volume: 90, Issue: 22

Year: 1993, Volume: 90, Issue: 21

Year: 1993, Volume: 90, Issue: 20

Year: 1993, Volume: 90, Issue: 19

Year: 1993, Volume: 90, Issue: 18

Year: 1993, Volume: 90, Issue: 17

Year: 1993, Volume: 90, Issue: 16

Year: 1993, Volume: 90, Issue: 15

Year: 1993, Volume: 90, Issue: 14

Transforming sensory experience into structural change.

Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.

Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries.

Targeting the site of RNA-RNA recombination in brome mosaic virus with antisense sequences.

Inhibition of type 1 human immunodeficiency virus replication by a tat antagonist to which the virus remains sensitive after prolonged exposure in vitro.

Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).

Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection.

Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.

Preferential and asymmetric interaction of linker histones with 5S DNA in the nucleosome.

Direct measurement of cyclic current-voltage responses of integral membrane proteins at a self-assembled lipid-bilayer-modified electrode: cytochrome f and cytochrome c oxidase.

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage.

Lipid advanced glycosylation: pathway for lipid oxidation in vivo.

Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

"Diabodies": small bivalent and bispecific antibody fragments.

Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.

Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.

Cell cycle regulation of nuclear localization of hepatitis B virus core protein.

Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation.

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

Yersinia enterocolitica invasin: a primary role in the initiation of infection.

Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study.

A cellular factor stimulates the DNA-binding activity of MyoD and E47.

A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus.

Kinetic control of Ca(II) signaling: tuning the ion dissociation rates of EF-hand Ca(II) binding sites.

A general two-metal-ion mechanism for catalytic RNA.

Single kinesin molecules crossbridge microtubules in vitro.

Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag.

Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element.

Short DNA sequences from the cytoplasm of mouse tumor cells induce immortalization of human lymphocytes in vitro.

Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes.

A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.

Ionotropic non-N-methyl-D-aspartate agonists induce retraction of dendritic spinules from retinal horizontal cells.

Milk and fat yields decline in bovine leukemia virus-infected Holstein cattle with persistent lymphocytosis.

Transmutation of a heme protein.

Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.

Stimulus-induced dissociation of alpha subunits of heterotrimeric GTP-binding proteins from the cytoskeleton of human neutrophils.

Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3).

Molecular characterization of a short interspersed repetitive element from tobacco that exhibits sequence homology to specific tRNAs.

A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII.

Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development.

A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes.

At day 8-8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro.

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerases.

Transcriptional arrest of yeast RNA polymerase II by Escherichia coli rho protein in vitro.

Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domain.

Heterologous expression of mating-type genes in filamentous fungi.

Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.

Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor.

Phytochrome-regulated expression of the genes encoding the small GTP-binding proteins in peas.

Disease risk as a cost of outbreeding in the termite Zootermopsis angusticollis.

Homologous recognition promoted by RecA protein via non-Watson-Crick bonds between identical DNA strands.

Cloning of human erythroid dematin reveals another member of the villin family.

DNA topoisomerase I is essential in Drosophila melanogaster.

VH gene organization in a relict species, the coelacanth Latimeria chalumnae: evolutionary implications.

Wavelengths effective in induction of malignant melanoma.

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

Lymphohemopoietic reconstitution using wheat germ agglutinin-positive hemopoietic stem cell transplantation within but not across the major histocompatibility antigen barriers.

Differential organ-specific expression of three poly(A)-binding-protein genes from Arabidopsis thaliana.

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

Tumors in hepatobiliary tract and pancreatic islet tissues of transgenic mice harboring gastrin simian virus 40 large tumor antigen fusion gene.

Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells.

Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.

Coexpression of neurotrophins and their receptors in neurons of the central nervous system.

Circumvention of prey defense by a predator: ant lion vs. ant.

The serum response element can mediate induction of c-fos by growth hormone.

A Jun-binding protein related to a putative tumor suppressor.

Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C.

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1.

Sequence analysis of the beta-N-acetylhexosaminidase gene of Vibrio vulnificus: evidence for a common evolutionary origin of hexosaminidases.

The Escherichia coli pcnB gene promotes adenylylation of antisense RNAI of ColE1-type plasmids in vivo and degradation of RNAI decay intermediates.

Primary structure elements responsible for the conformational switch in the envelope glycoprotein gp120 from human immunodeficiency virus type 1: LPCR is a motif governing folding.

Dimerization and DNA binding alter phosphorylation of Fos and Jun.

The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome.

An unusual RNA tertiary interaction has a role for the specific aminoacylation of a transfer RNA.

Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs.

Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

Construction of a yeast artificial chromosome contig spanning the spinal muscular atrophy disease gene region.

Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

Conserved structure of amphibian T-cell antigen receptor beta chain.

Cloning and characterization of cyclophilin C-associated protein: a candidate natural cellular ligand for cyclophilin C.

Even in culture, oligodendrocytes myelinate solely axons.

Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin.

A tobacco gene family for flower cell wall proteins with a proline-rich domain and a cysteine-rich domain.

Insect pheromone biosynthesis: stereochemical pathway of hydroxydanaidal production from alkaloidal precursors in Creatonotos transiens (Lepidoptera, Arctiidae).

Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein.

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

The functional form of the erythropoietin receptor is a 78-kDa protein: correlation with cell surface expression, endocytosis, and phosphorylation.

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

Intervening sequence with conserved open reading frame in eubacterial 23S rRNA genes.

The linker of des-Glu84-calmodulin is bent.

Genomic mapping with I-Ceu I, an intron-encoded endonuclease specific for genes for ribosomal RNA, in Salmonella spp., Escherichia coli, and other bacteria.

Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide.

Unusual microtubule-dependent endocytosis mechanisms triggered by Campylobacter jejuni and Citrobacter freundii.

Diazepam dependence prevented by glutamate antagonists.

Male-specific expression of mouse sex-limited protein requires growth hormone, not testosterone

Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb -tsA58 transgenic mice

Year: 1993, Volume: 90, Issue: 13

Year: 1993, Volume: 90, Issue: 12

Year: 1993, Volume: 90, Issue: 11

Year: 1993, Volume: 90, Issue: 10

Year: 1993, Volume: 90, Issue: 9

Year: 1993, Volume: 90, Issue: 8

Year: 1993, Volume: 90, Issue: 7

Year: 1993, Volume: 90, Issue: 6

Year: 1993, Volume: 90, Issue: 5

Year: 1993, Volume: 90, Issue: 4

Year: 1993, Volume: 90, Issue: 3

Year: 1993, Volume: 90, Issue: 2

Year: 1993, Volume: 90, Issue: 1

Year: 1992, Volume: 89

Year: 1991, Volume: 88

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

Diazepam dependence prevented by glutamate antagonists.

Content Provider	PubMed Central
Author	Steppuhn, K. G. Turski, L.
Abstract	Long-term treatment leads to tolerance to and dependence on benzodiazepines. Abrupt termination of benzodiazepine administration triggers the expression of signs of dependence. Mice withdrawn from chronic treatment with diazepam showed a time-related evolution of anxiety, muscle rigidity, and seizures between days 4 and 21 after treatment discontinuation. A period between withdrawal days 1 and 3 was symptom-free. Surprisingly, during this "silent phase" the susceptibility of mice to alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate (ATPA) and kainate seizures and the magnitude of monosynaptic reflexes mediated by non-N-methyl-D-aspartate (NMDA) mechanisms were enhanced. In apparent contrast, the "active phase", between withdrawal days 4 and 21, was characterized by increased susceptibility to NMDA seizures and enhanced magnitude of polysynaptic reflexes, which are NMDA dependent. Treatment of mice with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) antagonists 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466) or 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline but not with the NMDA antagonist 3-[(+/-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP) during the silent phase prevented signs of dependence. In contrast, treatment with CPP but not with GYKI 52466 during the active phase prevented the symptoms. The development of tolerance to and dependence on diazepam was prevented by concurrent treatment of mice with CPP but was not prevented by GYKI 52466. These data indicate that NMDA-dependent mechanisms contribute to the development of tolerance to diazepam and to the expression of signs of dependence in mice after termination of long-term treatment with diazepam. Nevertheless, the non-NMDA-mediated silent phase is essential for triggering the symptoms. Therefore, AMPA antagonists may offer a therapeutic approach for preventing dependence on benzodiazepines that is an alternative to NMDA antagonism.
Starting Page	6889
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	90
Language	English
Publisher Date	1993-07-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in