NDLI: Biocompatible oil core nanocapsules as potential co-carriers of paclitaxel and fluorescent markers: preparation, characterization, and bioimaging

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Biocompatible oil core nanocapsules as potential co-carriers of paclitaxel and fluorescent markers: preparation, characterization, and bioimaging

Content Provider	PubMed Central
Author	Drozdek, SÅ awomir BazyliÅ ska, Urszula
Abstract	The present work is focused on the long-term stability and in vitro cellular internalization of newly designed biocompatible polyester nanocapsules prepared via nanoprecipitation approach with mean diameter <165 nm and narrow size distribution, dedicated to theranostic applications. We monitored the optical, morphological, and biological properties of the nanocarriers loaded by multifunctional cargo, i.e., paclitaxel (PTX) and a fluorescent marker: coumarin-6 (CR-6) or Nile Red (NR), by fluorescence and UV–vis spectroscopy (encapsulation efficiency), dynamic light scattering (average size expressed as hydrodynamic diameter, D H), zeta potential (ζ, colloidal stability), atomic force microscopy (AFM, imaging), and confocal laser scanning microscopy (CLSM, nanocapsule visualization, and cellular internalization in vitro by human breast cancer MCF-7/WT cells). The fabricated nanocapsules with optimal composition of oleic phase, i.e., coconut oil, palm oil, and Capmul MCM, as well as polymeric shell, i.e., polylactic acid (PLA), poly (ε-caprolactone) (PCL), and poly (lactide-co-glycolide) (PLGA), showed high loading capacity, long-term stability, and improved localization of the active cargo in studied tumor cells. Therefore, our results prove that the studied polyester oil core nanocapsules provide lifelong and biocompatible nanocarriers suitable for in vivo administration and for diagnostic applications.
Related Links	http://dx.doi.org/10.1007/s00396-015-3767-5
Ending Page	237
Page Count	13
Starting Page	225
File Format	PDF
ISSN	0303402X
e-ISSN	14351536
Journal	Colloid and Polymer Science
Volume Number	294
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-01-01
Access Restriction	Open
Rights Holder	Springer Berlin Heidelberg
Subject Keyword	Physical and Theoretical Chemistry Colloid and Surface Chemistry Materials Chemistry Polymers and Plastics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics

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