NDLI: Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes

Content Provider	PubMed Central
Author	Rauf, Abdur Ali, Jawad Khan, Haroon Mubarak, Mohammad S. Patel, Seema
Abstract	Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer’s yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests. Various fractions of the extract exhibited marked dose-dependent (p < 0.05) sedative-hypnotic and antipyretic activities. The biological efficacies were most pronounced between 50 and 100 mg/kg. Further, the acetic acid-induced abdominal constrictions were significantly (p < 0.05) attenuated by the extract. Chloroform fraction of the extract was most dominant followed by ethyl acetate. The demonstrated therapeutic attributes of Z. nummularia extract can be exploited to isolate pharmaceutically relevant compounds.
Related Links	http://dx.doi.org/10.1007/s13205-015-0322-5
Starting Page	11
File Format	PDF
ISSN	2190572X
e-ISSN	21905738
Journal	3 Biotech
Issue Number	1
Volume Number	6
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-06-01
Access Restriction	Open
Rights Holder	Springer Berlin Heidelberg
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Environmental Science Agricultural and Biological Sciences Biotechnology

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