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| Content Provider | PubMed Central |
|---|---|
| Author | Jeon, Jane Kim, Yejin Kim, Hyemin Kang, Jae Seung Lee, Wang Jae |
| Copyright Year | 2015 |
| Abstract | Asthma is a well-known inflammatory lung disease; however, the specific underlying mechanism is largely unknown. We previously demonstrated that alloferon effectively downregulates pulmonary inflammation. In this study, we examined whether alloferon has a therapeutic effect on asthma. Alloferon remarkably decreased the number of eosinophils, macrophages, and neutrophils in the bronchoalveolar lavage fluid (BALF) from ovalbumin (OVA)-induced asthma mice. It was synergistically decreased with 2.5 mg/kg prednisolone (PDA). Inflammatory cell infiltration around the bronchioles and in the alveolus of OVA-induced asthma mice was effectively prevented by alloferon alone and combined treatment with alloferon and PDS. The production of IL-5 and IL-17 was decreased by alloferon alone and combined treatment with alloferon and PDS. There was no change the level of total immunoglobulin (Ig) following alloferon administration; however, total Ig was decreased by PDS. IgG2a levels were not changed by either alloferon alone or alloferon in combination with PDS. However, the levels of OVA-specific IgG1 and IgE were decreased by alloferon and PDS. In conclusion, our results suggest that a combination of alloferon and prednisolone is effective for the treatment of asthma, as it prevents inflammatory cell infiltration via the downregulation of IL-5 and IL-17 production and decreases IgG1 and IgE production via the suppression of T helper type 2 immune response. |
| Related Links | http://dx.doi.org/10.4110/in.2015.15.6.304 |
| Starting Page | 304 |
| File Format | |
| ISSN | 15982629 |
| e-ISSN | 20926685 |
| Journal | Immune Network |
| Issue Number | 6 |
| Volume Number | 15 |
| Language | English |
| Publisher | The Korean Association of Immunologists |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Rights Holder | The Korean Association of Immunologists |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy Immunology |
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