NDLI: Evolution of lineage-specific functions in ancient cis-regulatory modules

Please wait, while we are loading the content...

Evolution of lineage-specific functions in ancient cis-regulatory modules

Content Provider	PubMed Central
Author	Pauls, Stefan Goode, Debbie K. Petrone, Libero Oliveri, Paola Elgar, Greg
Copyright Year	2015
Abstract	Morphological evolution is driven both by coding sequence variation and by changes in regulatory sequences. However, how cis-regulatory modules (CRMs) evolve to generate entirely novel expression domains is largely unknown. Here, we reconstruct the evolutionary history of a lens enhancer located within a CRM that not only predates the lens, a vertebrate innovation, but bilaterian animals in general. Alignments of orthologous sequences from different deuterostomes sub-divide the CRM into a deeply conserved core and a more divergent flanking region. We demonstrate that all deuterostome flanking regions, including invertebrate sequences, activate gene expression in the zebrafish lens through the same ancient cluster of activator sites. However, levels of gene expression vary between species due to the presence of repressor motifs in flanking region and core. These repressor motifs are responsible for the relatively weak enhancer activity of tetrapod flanking regions. Ray-finned fish, however, have gained two additional lineage-specific activator motifs which in combination with the ancient cluster of activators and the core constitute a potent lens enhancer. The exploitation and modification of existing regulatory potential in flanking regions but not in the highly conserved core might represent a more general model for the emergence of novel regulatory functions in complex CRMs.
Related Links	http://dx.doi.org/10.1098/rsob.150079
Starting Page	150079
File Format	PDF
ISSN	20462441
e-ISSN	20462441
Journal	Open Biology
Issue Number	11
Volume Number	5
Language	English
Publisher	The Royal Society
Publisher Date	2015-11-01
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Biochemistry, Genetics and Molecular Biology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein–Uhlenbeck Models

Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein–Uhlenbeck Models

Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

Functional Evolution of a cis-Regulatory Module

The Evolution of Lineage-Specific Regulatory Activities in the Human Embryonic Limb

Intronic Cis-Regulatory Modules Mediate Tissue-Specific and Microbial Control of angptl4/fiaf Transcription

Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules

Lineage-specific transcription factors and the evolution of gene regulatory networks

Evolution of lineage-specific functions in ancient cis-regulatory modules

Similar Documents

Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein–Uhlenbeck Models

Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein–Uhlenbeck Models

Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

Functional Evolution of a cis-Regulatory Module

The Evolution of Lineage-Specific Regulatory Activities in the Human Embryonic Limb

Intronic Cis-Regulatory Modules Mediate Tissue-Specific and Microbial Control of angptl4/fiaf Transcription

Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules

Lineage-specific transcription factors and the evolution of gene regulatory networks

Evolution of lineage-specific functions in ancient cis-regulatory modules