NDLI: MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells

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MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells

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MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells

Content Provider	PubMed Central
Author	Knackmuss, U. Lindner, Se Aneichyk, T. Kotkamp, B. Knust, Z. Villunger, A. Herzog, S.
Abstract	MicroRNAs (miRNAs) are a class of small, non-coding RNAs that posttranscriptionally regulate gene expression and thereby control most, if not all, biological processes. Aberrant miRNA expression has been linked to a variety of human diseases including cancer, but the underlying molecular mechanism often remains unclear. Here we have screened a miRNA expression library in a growth factor-dependent mouse pre-B-cell system to identify miRNAs with oncogenic activity. We show that miR-125b is sufficient to render pre-B cells growth factor independent and demonstrate that continuous expression of miR-125b is necessary to keep these cells in a transformed state. Mechanistically, we find that the expression of miR-125b protects against apoptosis induced by growth factor withdrawal, and that it blocks the differentiation of pre-B to immature B cells. In consequence, miR-125b-transformed cells maintain expression of their pre-B-cell receptor that provides signals for continuous proliferation and survival even in the absence of growth factor. Employing microarray analysis, we identified numerous targets of miR-125b, but only reconstitution of MAP3K11, a critical regulator of mitogen- and stress-activated kinase signaling, interferes with the cellular fitness of the transformed cells. Together, this indicates that MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia.
Related Links	http://dx.doi.org/10.1038/cdd.2015.87
Starting Page	242
File Format	PDF
ISSN	14765403
e-ISSN	14765403
Journal	Cell death and differentiation
Issue Number	2
Volume Number	23
Language	English
Publisher Date	2016-02-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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