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Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes
| Content Provider | PubMed Central |
|---|---|
| Author | Sanjabi, Bahram Dashty, Monireh Özcan, Behiye Akbarkhanzadeh, Vishtaseb Rahimi, Mehran Vinciguerra, Manlio Rooij, Felix Van Saad, Al-lahham Sheedfar, Fareeba Kooten, Theo G. Van Spek, C. Arnold Rowshani, Ajda T. Want, Johannes Van Der Klaassen, Rene Sijbrands, Eric Peppelenbosch, Maikel P. Rezaee, Farhad |
| Copyright Year | 2015 |
| Abstract | Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with insulin regulation is unknown in humans. Human adipocytes constitutively synthesize and secrete insulin, which is biologically functional. Insulin concentrations and release are fat mass- and LDs-dependent respectively. Fat reduction mediated by bariatric surgery repairs obesity-associated T2D. The expression of genes, like PCSK1 (proinsulin conversion enzyme), GCG (Glucagon), GPLD1, CD38 and NNAT, involved in insulin regulation/release were differentially expressed in pancreas and adipose tissue (AT). INS (insulin) and GCG expression reduced in human AT-T2D as compared to AT-control, but remained unchanged in pancreas in either state. Insulin levels (mRNA/protein) were higher in AT derived from prediabetes BB rats with destructed pancreatic β-cells and controls than pancreas derived from the same rats respectively. Insulin expression in 10 human primary cell types including adipocytes and macrophages is an evidence for extrapancreatic insulin-producing cells. The data suggest a crosstalk between AT and pancreas to fine-tune energy metabolic system or may minimize the metabolic damage during diabetes. This study opens new avenues towards T2D therapy with a great impact on public health. |
| Related Links | http://dx.doi.org/10.1038/srep08816 |
| Starting Page | 8816 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 5 |
| Language | English |
| Publisher | Nature Publishing Group |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
