NDLI: Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm

Content Provider	PubMed Central
Author	Korek, Michal J. Bellander, Tom D. Lind, Tomas Bottai, Matteo Eneroth, Kristina M. Caracciolo, Barbara Faire, Ulf H. De Laura, Fratiglioni Hilding, Agneta Leander, Karin Magnusson, Patrik K. E. Pedersen, Nancy L. Östenson, Claes-göran Pershagen, Göran Penell, Johanna C.
Copyright Year	2015
Abstract	We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air pollution levels resulting from local road traffic emissions were assessed at participant residences using dispersion models for particulate matter (PM10) and nitrogen oxides (NOX). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20 μg/m3 in estimated annual mean of road-traffic related NOX exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83–1.61), with evidence of heterogeneity between the cohorts. For PM10, an increment of 10 μg/m3 corresponded to a hazard ratio of 1.14 (95% CI 0.68–1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NOX and PM10 from local traffic and stroke at comparatively low levels of air pollution.
Related Links	http://dx.doi.org/10.1038/jes.2015.22
Ending Page	523
Page Count	7
Starting Page	517
File Format	PDF
ISSN	15590631
e-ISSN	1559064X
Journal	Journal of Exposure Science & Environmental Epidemiology
Issue Number	5
Volume Number	25
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-09-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Toxicology Public Health, Environmental and Occupational Health Epidemiology Pollution Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pollution Public Health, Environmental and Occupational Health Toxicology Epidemiology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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