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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Wenming Liu, Xiang Wang, Xu Dong, Hui Ma, Chao Wang, Jingmin Liu, Baocheng Mao, Yonghong Wang, Ying Li, Ting Yang, Cheng Guo, Yu |
| Editor | López, S. |
| Copyright Year | 2015 |
| Abstract | The nairoviruses include assorted tick-borne bunyaviruses that are emerging as causative agents of infectious diseases among humans and animals. As negative-sense single-stranded RNA (−ssRNA) viruses, nairoviruses encode nucleoprotein (NP) that encapsidates the genomic RNA and further forms ribonucleoprotein (RNP) complex with viral RNA-dependent RNA polymerase (RdRp). We previously revealed that the monomeric NP encoded by Crimean-Congo hemorrhagic fever virus (CCHFV) presents a racket-shaped structure and shows unusual DNA-specific endonuclease activity. To examine the structural and biological variation of nairovirus-encoded NPs, here, we systematically solved the crystal structures of NPs encoded by various nairoviruses, including Hazara virus (HAZV), Kupe virus (KUPV), and Erve virus (ERVEV). Combined with biochemical analysis, our results generate a clearer picture to aid in the understanding of the functional diversity of nairovirus-encoded NPs and the formation of nairovirus RNPs. |
| Related Links | http://dx.doi.org/10.1128/jvi.01680-15 |
| Ending Page | 11749 |
| Page Count | 10 |
| Starting Page | 11740 |
| File Format | |
| ISSN | 0022538X |
| e-ISSN | 10985514 |
| Journal | Journal of Virology |
| Issue Number | 23 |
| Volume Number | 89 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2015-12-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Virology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology Insect Science |
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