NDLI: VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish

Content Provider	PubMed Central
Author	Jensen, Lasse D. Nakamura, Masaki Bräutigam, Lars Li, Xuri Liu, Yizhi Samani, Nilesh J. Cao, Yihai
Abstract	We provide one of the few examples of spatiotemporal expression of VEGF-A and VEGF-B, which determine vascular development in zebrafish embryos. Nonoverlapping vascular functions of VEGF-A and VEGF-B are regulated by environmental oxygen tension. We show, for the first time to our knowledge, that downregulation of VEGF-B in zebrafish but not in mouse embryos produces a lethal phenotype owing to vascular defects. These findings indicate that different species use distinct mechanisms by the same factor for vascular development. Our data imply previously unidentified mechanisms for angiogenesis under pathological conditions as compared with healthy counterparts. Thus, differential targeting of the same VEGF-B in pathological and physiological angiogenesis may be potentially achieved by understanding spatiotemporal mechanisms of VEGF-B in relation to VEGF-A.
Related Links	http://dx.doi.org/10.1073/pnas.1510245112
Starting Page	5944
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	44
Volume Number	112
Language	English
Publisher	National Academy of Sciences
Publisher Date	2015-11-03
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish