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| Content Provider | PubMed Central |
|---|---|
| Author | Christos, Sachpekidis Mosebach, Jennifer Freitag, Martin T. Wilhelm, Thomas Mai, Elias K. Goldschmidt, Hartmut Haberkorn, Uwe Schlemmer, Heinz-peter Delorme, Stefan Antonia, Dimitrakopoulou-strauss |
| Copyright Year | 2015 |
| Abstract | Aim of this prospective study was to assess the sensitivity of positron emission tomography (PET) and diffusion-weighted imaging (DWI) in detecting multiple myeloma (MM) lesions, using the well-established morphologic modalities magnetic resonance imaging (MRI) and computed tomography (CT) as the standard of reference (RS). The study included 24 MM patients (15 newly diagnosed, 9 pre-treated). All underwent 18F-FDG PET/CT and wholebody DWI. The findings in PET and DWI were compared to matching imaging findings in combined non-enhanced T1w, fat-saturated T2w (TIRM)- MRI, and low-dose CT. Patient-based analysis revealed that 15/24 patients (10 primary MM, 5 pre-treated) had myeloma lesions according to our RS. PET was positive in 13/24 patients (11 primary MM, 2 pre-treated) and DWI in 18/24 patients (12 primary MM, 6 pre-treated). Lesion-based analysis demonstrated 128 MM lesions, of which PET depicted 60/128 lesions (sensitivity 47%), while DWI depicted 99/128 lesions (sensitivity 77%). Further analysis including only the 15 untreated MM patients revealed a sensitivity of 90% for both PET and DWI and an overall concordance of PET and DWI of 72%. In conclusion, DWI was more sensitive than 18F-FDG PET in detecting myeloma lesions in a mixed population of primary and pre-treated MM patients. However, 18F-FDG PET and DWI demonstrated equivalent sensitivities in the sub-population of primary, untreated MM patients. This higher sensitivity of DWI in pre-treated patients may be due to the fact that 18F-FDG PET becomes negative earlier in the course of treatment in contrary to MRI, in which already treated lesions can remain visible. |
| Ending Page | 492 |
| Starting Page | 479 |
| File Format | |
| ISSN | 21608407 |
| e-ISSN | 21608407 |
| Journal | American Journal of Nuclear Medicine and Molecular Imaging |
| Issue Number | 5 |
| Volume Number | 5 |
| Language | English |
| Publisher | e-Century Publishing Corporation |
| Publisher Date | 2015-10-12 |
| Access Restriction | Open |
| Rights Holder | e-Century Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
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