NDLI: Invariant Characteristics of Carcinogenesis

Content Provider	PubMed Central
Author	Sherman, Simon Rathnayake, Nirosha Mdzinarishvili, Tengiz
Editor	Calogero, Raffaele A.
Copyright Year	2015
Abstract	Carcinogenic modeling is aimed at mathematical descriptions of cancer development in aging. In this work, we assumed that a small fraction of individuals in the population is susceptible to cancer, while the rest of the population is resistant to cancer. For individuals susceptible to cancer we adopted methods of conditional survival analyses. We performed computational experiments using data on pancreatic, stomach, gallbladder, colon and rectum, liver, and esophagus cancers from the gastrointestinal system collected for men and women in the SEER registries during 1975–2009. In these experiments, we estimated the time period effects, the birth cohort effects, the age effects and the population (unconditional) cancer hazard rates. We also estimated the individual cancer presentation rates and the individual cancer resistance rates, which are, correspondingly, the hazard and survival rates conditioned on the susceptibility to cancer. The performed experiments showed that for men and women, patterns of the age effects, the individual cancer presentation rates and the individual cancer resistance rates are: (i) intrinsic for each cancer subtype, (ii) invariant to the place of living of the individuals diagnosed with cancer, and (iii) well adjusted for the modifiable variables averaged at a given time period. Such specificity and invariability of the age effects, the individual cancer presentation rates and the individual cancer resistance rates suggest that these carcinogenic characteristics can be useful for predictive carcinogenic studies by methods of inferential statistics and for the development of novel strategies for cancer prevention.
Related Links	http://dx.doi.org/10.1371/journal.pone.0140405
Starting Page	140405
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	10
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-10-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genetic Characteristics of Mitochondrial DNA Was Associated with Colorectal Carcinogenesis and Its Prognosis

Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

Functional Role of NRF2 in Cervical Carcinogenesis

Exocrine Pancreatic Carcinogenesis and Autotaxin Expression

Association of p62/SQSTM1 Excess and Oral Carcinogenesis

Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis

Experimental Gastric Carcinogenesis in Cebus apella Nonhuman Primates

Unimpaired Skin Carcinogenesis in Desmoglein 3 Knockout Mice

Stoichiometry of HLA Class II-Invariant Chain Oligomers

Invariant Characteristics of Carcinogenesis

Similar Documents

Genetic Characteristics of Mitochondrial DNA Was Associated with Colorectal Carcinogenesis and Its Prognosis

Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

Functional Role of NRF2 in Cervical Carcinogenesis

Exocrine Pancreatic Carcinogenesis and Autotaxin Expression

Association of p62/SQSTM1 Excess and Oral Carcinogenesis

Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis

Experimental Gastric Carcinogenesis in Cebus apella Nonhuman Primates

Unimpaired Skin Carcinogenesis in Desmoglein 3 Knockout Mice

Stoichiometry of HLA Class II-Invariant Chain Oligomers

Invariant Characteristics of Carcinogenesis