NDLI: Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment.

Please wait, while we are loading the content...

Year: 2016, Volume: 35

Year: 2015, Volume: 34

Year: 2014, Volume: 33

Year: 2013, Volume: 33

Year: 2013, Volume: 32

Year: 2012, Volume: 32

Year: 2012, Volume: 31

Year: 2011, Volume: 30

Year: 2010, Volume: 29

Year: 2009, Volume: 28

Year: 2008, Volume: 27

Year: 2007, Volume: 26

Year: 2006, Volume: 26

Year: 2006, Volume: 25

Year: 2005, Volume: 24

Year: 2004, Volume: 24

Year: 2004, Volume: 23

Year: 2003, Volume: 22

Year: 2002, Volume: 21

Year: 2001, Volume: 20

Year: 2000, Volume: 19

Year: 1999, Volume: 18

Year: 1998, Volume: 17

Year: 1997, Volume: 16

Year: 1996, Volume: 15

Year: 1995, Volume: 14

Year: 1994, Volume: 13

Year: 1993, Volume: 12

Year: 1992, Volume: 11

Year: 1991, Volume: 10

Year: 1990, Volume: 9

Year: 1989, Volume: 8

Year: 1988, Volume: 7

Year: 1988, Volume: 7, Issue: 13

Year: 1988, Volume: 7, Issue: 12

Year: 1988, Volume: 7, Issue: 11

Year: 1988, Volume: 7, Issue: 10

Year: 1988, Volume: 7, Issue: 9

Year: 1988, Volume: 7, Issue: 8

Year: 1988, Volume: 7, Issue: 7

Year: 1988, Volume: 7, Issue: 6

Leaf-specific thionins of barley—a novel class of cell wall proteins toxic to plant-pathogenic fungi and possibly involved in the defence mechanism of plants

Novel mechanisms for maturation of chloroplast transfer RNA precursors

Two concomitant base substitutions in the putative replicase genes of tobacco mosaic virus confer the ability to overcome the effects of a tomato resistance gene, Tm-1

The intergenic region of maize streak virus contains promoter elements involved in rightward transcription of the viral genome

The three-dimensional structure of P2 myelin protein.

Identification of domains involved in nuclear uptake and histone binding of protein N1 of Xenopus laevis.

Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase.

Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment.

Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

Expression of human estrogen receptor mutants in Xenopus oocytes: correlation between transcriptional activity and ability to form protein-DNA complexes.

Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments.

Thymocyte circular DNA excised from T cell receptor alpha-delta gene complex.

The structure of the human CD2 gene and its expression in transgenic mice.

Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line.

Alpha-interferon inhibits the expression of heavy chain mu messenger RNA in Daudi cells.

Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex.

Biogenesis of the yeast lysosome (vacuole): biosynthesis and maturation of proteinase yscB.

Two distinct factors interact with the promoter regions of several liver-specific genes.

Tissue specific trans-acting factor interaction with proximal rat prolactin gene promoter sequences.

The finger motif defines a multigene family represented in the maternal mRNA of Xenopus laevis oocytes.

Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

Sorting of soluble ER proteins in yeast.

Post-translational transport of proteins into microsomal membranes of Candida maltosa.

The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length.

Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA.

Partial purification and substrate analysis of bacterially expressed HIV protease by means of monoclonal antibody.

Dissection of functional domains of the yeast proton-pumping ATPase by directed mutagenesis.

Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site for the HAP1 (CYP1) protein in the UAS region of the yeast catalase T gene (CTT1).

Multiple regulatory mechanisms control the expression of the RAS1 and RAS2 genes of Saccharomyces cerevisiae.

Comparison of the in vitro transforming activities of human papillomavirus types.

The nucleocapsid of bacteriophage phi 6 penetrates the host cytoplasmic membrane.

ProOmpA spontaneously folds in a membrane assembly competent state which trigger factor stabilizes.

Effect of anti-cruciform DNA monoclonal antibodies on DNA replication.

The functional significance of DNA sequence structure in a site-specific genetic recombination reaction.

The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell.

DNA supercoiling and the leu-500 promoter mutation of Salmonella typhimurium.

Correlation between the conformation of Escherichia coli -10 hexamer sequences and promoter strength: use of orthophenanthroline cuprous complex as a structural index.

Recognition of the P1 plasmid centromere analog involves binding of the ParB protein and is modified by a specific host factor.

The partition locus of plasmid pSC101 is a specific binding site for DNA gyrase.

Isolation and characterization of the Tn3 resolvase synaptic intermediate.

Gamma delta transposase and integration host factor bind cooperatively at both ends of gamma delta.

Year: 1988, Volume: 7, Issue: 5

Year: 1988, Volume: 7, Issue: 4

Year: 1988, Volume: 7, Issue: 3

Year: 1988, Volume: 7, Issue: 2

Year: 1988, Volume: 7, Issue: 1

Year: 1987, Volume: 6

Year: 1986, Volume: 5

Year: 1985, Volume: 4

Year: 1984, Volume: 3

Year: 1983, Volume: 2

Year: 1982, Volume: 1

Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment.

Content Provider	PubMed Central
Author	Issinger, O. G. Martin, T. Richter, W. W. Olson, M. Fujiki, H.
Abstract	Okadaic acid, a non-TPA-type tumour promoter, induces hyperphosphorylation of a 60-kd protein in primary human fibroblasts. Treatment with TPA-type tumour promoters (e.g. TPA and teleocidin) did not cause this hyperphosphorylation. Phosphorylation of this protein was not seen at times earlier than 90 min after the addition of 75 ng/ml okadaic acid to the proliferating cell cultures. The presence of inhibitors such as actinomycin D and cycloheximide, did not significantly influence the level of hyperphosphorylation induced by okadaic acid treatment. By immunoblotting using an antibody anti-nucleolin, the 60-kd protein was identified as a fragment of nucleolar protein, nucleolin. Similarly, antibodies against the 60-kd protein cross-reacted with nucleolin. Furthermore peptide mapping, using staphylococcal V8 protease, showed that the 60-kd protein phosphorylated by casein kinase II in vitro and the okadaic-acid-induced hyperphosphorylated 60-kd protein exhibited identical phosphopeptide maps, indicating that there is also structural relatedness between N-60 and nucleolin. Hyperphosphorylation of the nucleolin fragment (N-60) was suppressed by anti-tumour promoter retinoic acid.
Starting Page	1621
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	6
Volume Number	7
Language	English
Publisher Date	1988-06-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in