NDLI: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism

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Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism

Content Provider	PubMed Central
Author	Patel, Bhavesh H. Claudia, Percivalle Ritson, Dougal J. Duffy, Colm D. Sutherland, John D.
Abstract	A minimal cell can be thought of as comprising informational, compartment-forming and metabolic subsystems. Imagining the abiotic assembly of such an overall system, however, places great demands on hypothetical prebiotic chemistry. The perceived differences and incompatibilities between these subsystems have led to the widely held assumption that one or other subsystem must have preceded the others. Here, we have experimentally investigated the validity of this assumption by examining the assembly of various biomolecular building blocks from prebiotically plausible intermediates and one-carbon feedstock molecules. We show that precursors of ribonucleotides, amino acids and lipids can all be derived by reductive homologation of hydrogen cyanide and some of its derivatives and thus that all the cellular subsystems could have arisen simultaneously through common chemistry. The key reaction steps are driven by UV light, use hydrogen sulfide as reductant and can be accelerated by Cu(I)-Cu(II) photoredox cycling.
Related Links	http://dx.doi.org/10.1038/nchem.2202
Ending Page	307
Page Count	7
Starting Page	301
File Format	PDF
ISSN	17554349
e-ISSN	17554349
Journal	Nature chemistry
Issue Number	4
Volume Number	7
Language	English
Publisher Date	2015-04-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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