NDLI: The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task

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The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task

Content Provider	PubMed Central
Author	Ciano, Patricia Di Pushparaj, Abhiram Kim, Aaron Hatch, Jessica Masood, Talal Ramzi, Abby Khaled, Maram A. T. M. Boileau, Isabelle Winstanley, Catherine A. Foll, Bernard Le
Editor	Mccutcheon, James Edgar
Copyright Year	2015
Abstract	Gambling is an addictive disorder with serious societal and personal costs. To-date, there are no approved pharmacological treatments for gambling disorder. Evidence suggests a role for dopamine in gambling disorder and thus may provide a therapeutic target. The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically. In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods. As in the Iowa gambling task, the optimal strategy is to avoid the tempting high-risk high-reward options, and instead favor those linked to smaller per-trial rewards but also lower punishments, thereby maximizing the amount of reward earned over time. Administration of those selective ligands did not affect decision making under the rGT. Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task.
Related Links	http://dx.doi.org/10.1371/journal.pone.0136267
Starting Page	136267
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	9
Volume Number	10
Language	English
Publisher	Public Library of Science
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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