NDLI: Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine

Content Provider	PubMed Central
Author	Silvia, Rocchiccioli Cecchettini, Antonella Nadia, Ucciferri Terreni, Marianna Viglione, Federica Trivella, Maria Giovanna Citti, Lorenzo Parodi, Oberdan Pelosi, Gualtiero
Copyright Year	2015
Abstract	A major drawback in coronary atherosclerosis (ATS) research is the difficulty of investigating early phase of plaque growth and related features in the clinical context. In this study, secreted proteins from atherosclerotic coronary arteries in a hypercholesterolemic swine model were characterized by a proteomics approach and their expression was correlated to site-specific ATS stage and extent. A wide coronary artery map of secreted proteins has been obtained in high fat (HF) diet induced ATS swine model and a significantly different expression of many proteins related to vascular smooth muscle cell (VSMC) activation/migration has been identified. Significant associations with ATS stage of HF coronary lesions were found for several VSMC-derived proteins and validated for chitinase 3 like protein 1 (CHI3L1) by tissue immunoexpression. A direct correlation (R 2 = 0.85) was evidenced with intima to media thickness ratio values and ELISA confirmed the higher blood concentrations of CHI3L1 in HF cases. These findings confirmed the pivotal role of VSMCs in coronary plaque development and demonstrated a strong site-specific relation between VSMC-secreted CHI3L1 and lesion grade, suggesting that this protein could be proposed as a useful biomarker for diagnosing and staging of atherosclerotic lesions in coronary artery disease.
Related Links	http://dx.doi.org/10.1155/2015/465242
Starting Page	465242
File Format	PDF
ISSN	02780240
e-ISSN	18758630
Journal	Disease Markers
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Clinical Biochemistry Genetics Molecular Biology Biochemistry, medical Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Genetics Clinical Biochemistry Molecular Biology

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