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| Content Provider | PubMed Central |
|---|---|
| Author | Walsh, Megan Fais, Stefano Spugnini, Enrico Pierluigi Harguindey, Salvador Abu, Izneid Tareq Scacco, Licia Williams, Paula Allegrucci, Cinzia Rauch, Cyril Omran, Ziad |
| Abstract | The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancerous cells thus resulting in many side effects. A recent therapeutic approach takes advantage of the altered acidity of the tumour microenvironment by using proton pump inhibitors (PPIs) to block the hydrogen transport out of the cell. The alteration of the extracellular pH kills tumour cells, reverses drug resistance, and reduces cancer metastasis. Human clinical trials have prompted to consider this as a viable and safe option for the treatment of cancer in companion animals. Preliminary animal studies suggest that the same positive outcome could be achievable. The purpose of this review is to support investigations into the use of PPIs for cancer treatment cancer in companion animals by considering the evidence available in both human and veterinary medicine. |
| Related Links | http://dx.doi.org/10.1186/s13046-015-0204-z |
| Starting Page | 93 |
| File Format | |
| ISSN | 17569966 |
| e-ISSN | 17569966 |
| Journal | Journal of Experimental & Clinical Cancer Research : CR |
| Issue Number | 1 |
| Volume Number | 34 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2015-12-01 |
| Access Restriction | Open |
| Rights Holder | BioMed Central |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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