NDLI: The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

Content Provider	PubMed Central
Author	Lee, Chung-te Chen, I-tung Yang, Yi-ting Ko, Tzu-ping Huang, Yun-tzu Huang, Jiun-yan Huang, Ming-fen Lin, Shin-jen Chen, Chien-yu Lin, Shih-shun Lightner, Donald V. Wang, Han-ching Wang, Andrew H. J. Wang, Hao-ching Hor, Lien-i Lo, Chu-fang
Abstract	Since 2009, an emergent shrimp disease, acute hepatopancreatic necrosis disease (AHPND), has been causing global losses to the shrimp farming industry. The causative agent of AHPND is a specific strain of Vibrio parahaemolyticus. We present evidence here that the opportunistic V. parahaemolyticus becomes highly virulent by acquiring a unique AHPND-associated plasmid. This virulence plasmid, which encodes a binary toxin [V. parahaemolyticus Photorhabdus insect-related toxins (PirA vp and PirB vp )] that induces cell death, is stably inherited via a postsegregational killing system and disseminated by conjugative transfer. The cytotoxicity of the PirA vp /PirB vp system is analogous to the structurally similar insecticidal pore-forming Cry toxin. These findings will significantly increase our understanding of this emerging disease, which is essential for developing anti-AHPND measures.
Related Links	http://dx.doi.org/10.1073/pnas.1503129112
Ending Page	10803
Page Count	6
Starting Page	10798
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	34
Volume Number	112
Language	English
Publisher	National Academy of Sciences
Publisher Date	2015-08-25
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Correction for Lee et al., The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin.

Draft Genome Sequence of the Opportunistic Marine Pathogen Vibrio harveyi Strain E385

Oleic Acid Produced by a Marine Vibrio spp. Acts as an Anti-Vibrio parahaemolyticus Agent

Qualitative and Quantitative Detection of Potentially Virulent Vibrio parahaemolyticus in Drinking Water and Commonly Consumed Aquatic Products by Loop-Mediated Isothermal Amplification

Two replication regions in the pJM1 virulence plasmid of the marine pathogen Vibrio anguillarum

Complete Genome Sequence of the Marine Fish Pathogen Vibrio anguillarum Harboring the pJM1 Virulence Plasmid and Genomic Comparison with Other Virulent Strains of V. anguillarum and V. ordalii ▿ †

Editorial: Ecology, Virulence, and Detection of Pathogenic and Pandemic Vibrio parahaemolyticus

Complete Sequence of Virulence Plasmid pJM1 from the Marine Fish Pathogen Vibrio anguillarum Strain 775

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

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Correction for Lee et al., The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

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