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| Content Provider | PubMed Central |
|---|---|
| Author | Zhang, Wei Bi, Sheng |
| Copyright Year | 2015 |
| Abstract | Obesity and diabetes are increasing at an alarming rate worldwide, but the strategies for the prevention and treatment of these disorders remain inadequate. Brown adipose tissue (BAT) is important for cold protection by producing heat using lipids and glucose as metabolic fuels. This thermogenic action causes increased energy expenditure and significant lipid/glucose disposal. In addition, BAT in white adipose tissue (WAT) or beige cells have been found and they also exhibit the thermogenic action similar to BAT. These data provide evidence indicating BAT/beige cells as a potential target for combating obesity and diabetes. Recent discoveries of active BAT and beige cells in adult humans have further highlighted this potential. Growing studies have also shown the importance of central nervous system in the control of BAT thermogenesis and WAT browning using animal models. This review is focused on central neural thermoregulation, particularly addressing our current understanding of the importance of hypothalamic neural signaling in the regulation of BAT/beige thermogenesis and energy homeostasis. |
| Related Links | http://dx.doi.org/10.3389/fendo.2015.00136 |
| Starting Page | 136 |
| File Format | |
| ISSN | 16642392 |
| e-ISSN | 16642392 |
| Journal | Frontiers in Endocrinology |
| Volume Number | 6 |
| Language | English |
| Publisher | Frontiers Media S.A. |
| Publisher Date | 2015-08-01 |
| Access Restriction | Open |
| Rights Holder | Frontiers Media S.A. |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism |
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