NDLI: Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic

Content Provider	PubMed Central
Author	Mcauley, Julie L. Kedzierska, Katherine Brown, Lorena E. Shanks, G. Dennis
Copyright Year	2015
Abstract	During the 1918 influenza pandemic, healthy young adults unusually succumbed to infection and were considered more vulnerable than young children and the elderly. The pathogenesis of this pandemic in the young adult population remains poorly understood. As this population is normally the least likely to die during seasonal influenza outbreaks, thought to be due to their appropriate pre-existing and robust immune responses protecting them from infection, we sought to review existing literature for immunological reasons for excessive mortality during the 1918 pandemic. We propose the novelty of the H1N1 pandemic virus to an H1N1 naïve immune system, the virulence of this virus, and dysfunctional host inflammatory and immunological responses, shaped by past influenza infections could have each contributed to their overall susceptibility. Additionally, in the young adult population, pre-exposure to past influenza infection of different subtypes, such as a H3N8 virus, during their infancy in 1889–1892, may have shaped immunological responses and enhanced vulnerability via humoral immunity effects with cross-reactive or non-neutralizing antibodies; excessive and/or ineffective cellular immunity from memory T lymphocytes; and innate dysfunctional inflammation. Multiple mechanisms likely contributed to the increased young adult mortality in 1918 and are the focus of this review.
Related Links	http://dx.doi.org/10.3389/fimmu.2015.00419
Starting Page	419
File Format	PDF
ISSN	16643224
e-ISSN	16643224
Journal	Frontiers in Immunology
Volume Number	6
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2015-08-19
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic

Mortality Risk Factors During the 1918–1919 Influenza Pandemic in the Australian Army

Age- and Sex-Specific Mortality Associated With the 1918–1919 Influenza Pandemic in Kentucky

Pathogenic Responses among Young Adults during the 1918 Influenza Pandemic

Efficacy of Whole-Cell Killed Bacterial Vaccines in Preventing Pneumonia and Death during the 1918 Influenza Pandemic

Stillbirth Risk during the 1918 Influenza Pandemic in Arizona, USA

Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality

Racial Disparities in Mortality During the 1918 Influenza Pandemic in United States Cities

Epidemiologic Characterization of the 1918 Influenza Pandemic Summer Wave in Copenhagen: Implications for Pandemic Control Strategies

Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic

Similar Documents

Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic

Mortality Risk Factors During the 1918–1919 Influenza Pandemic in the Australian Army

Age- and Sex-Specific Mortality Associated With the 1918–1919 Influenza Pandemic in Kentucky

Pathogenic Responses among Young Adults during the 1918 Influenza Pandemic

Efficacy of Whole-Cell Killed Bacterial Vaccines in Preventing Pneumonia and Death during the 1918 Influenza Pandemic

Stillbirth Risk during the 1918 Influenza Pandemic in Arizona, USA

Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality

Racial Disparities in Mortality During the 1918 Influenza Pandemic in United States Cities

Epidemiologic Characterization of the 1918 Influenza Pandemic Summer Wave in Copenhagen: Implications for Pandemic Control Strategies

Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic