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| Content Provider | PubMed Central |
|---|---|
| Author | Hansen, Scott B. |
| Abstract | The past decade, membrane signaling lipids emerged as major regulators of ion channel function. However, the molecular nature of lipid binding to ion channels remained poorly described due to a lack of structural information and assays to quantify and measure lipid binding in a membrane. How does a lipid-ligand bind to a membrane protein in the plasma membrane and what does it mean for a lipid to activate or regulate an ion channel? How does lipid-binding compare to activation by soluble neurotransmitter? And how does the cell control lipid agonism? This review focuses on lipids and their interactions with membrane proteins, in particular ion channels. I discuss the intersection of membrane lipid biology and ion channel biophysics. A picture emerges of membrane lipids as bona fide agonists of ligand-gated ion channels. These freely diffusing signals reside in the plasma membrane, bind to the transmembrane domain of protein, and cause a conformational change that allosterically gates an ion channel. The system employs a catalog of diverse signaling lipids ultimately controlled by lipid enzymes and raft localization. I draw upon pharmacology, recent protein structure, and electrophysiological data to understand lipid regulation and define inward rectifying potassium channels (Kir) as a new class of PIP2 lipid-gated ion channels. |
| Related Links | http://dx.doi.org/10.1016/j.bbalip.2015.01.011 |
| Ending Page | 628 |
| Page Count | 9 |
| Starting Page | 620 |
| File Format | |
| ISSN | 13881981 |
| Journal | Biochimica et biophysica acta |
| Issue Number | 5 |
| Volume Number | 1851 |
| Language | English |
| Publisher Date | 2015-05-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
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