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| Content Provider | PubMed Central |
|---|---|
| Author | Oliveira, Lucas Felipe De Almeida, Thalles Ramos Machado, Marcus Paulo Ribeiro Cuba, Marilia Beatriz Alves, Angélica Cristina Silva, Marcos Vinícius Da Júnior, Virmondes Rodrigues Silva, Valdo José Dias Da |
| Copyright Year | 2015 |
| Abstract | Systemic arterial hypertension (SAH), a clinical syndrome characterized by persistent elevation of arterial pressure, is often associated with abnormalities such as microvascular rarefaction, defective angiogenesis, and endothelial dysfunction. Mesenchymal stem cells (MSCs), which normally induce angiogenesis and improve endothelial function, are defective in SAH. The central aim of this study was to evaluate whether priming of MSCs with endothelial growth medium (EGM-2) increases their therapeutic effects in spontaneously hypertensive rats (SHRs). Adult female SHRs were administered an intraperitoneal injection of vehicle solution (n = 10), MSCs cultured in conventional medium (DMEM plus 10% FBS, n = 11), or MSCs cultured in conventional medium followed by 72 hours in EGM-2 (pMSC, n = 10). Priming of the MSCs reduced the basal cell death rate in vitro. The administration of pMSCs significantly induced a prolonged reduction (10 days) in arterial pressure, a decrease in cardiac hypertrophy, an improvement in endothelium-dependent vasodilation response to acetylcholine, and an increase in skeletal muscle microvascular density compared to the vehicle and MSC groups. The transplanted cells were rarely found in the hearts and kidneys. Taken together, our findings indicate that priming of MSCs boosts stem cell therapy for the treatment of SAH. |
| Related Links | http://dx.doi.org/10.1155/2015/685383 |
| Starting Page | 685383 |
| File Format | |
| ISSN | 1687966X |
| e-ISSN | 16879678 |
| Journal | Stem Cells International |
| Volume Number | 2015 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Stem Cells International Healthcare Stem Cell genetics Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
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