NDLI: Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium

Content Provider	PubMed Central
Author	Song, You Salbu, Brit Teien, Hans-christian Heier, Lene Sørlie Rosseland, Bjørn Olav Tore, Høgåsen Tollefsen, Knut Erik
Copyright Year	2014
Abstract	Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of radionuclide is still lacking. The current article introduces transcriptomic data generated from a recent ecotoxicological study, with the aims to characterize the MoAs of a metallic radionuclide, deplete uranium (DU) in an ecologically and commercially important fish species, Atlantic salmon (Salmo salar). Salmon were exposed to three concentrations (0.25, 0.5 and 1.0 mg/L) of DU for 48 h. Short-term global transcriptional responses were studied using Agilent custom-designed high density 60,000-feature (60 k) salmonid oligonucleotide microarrays (oligoarray). The microarray datasets deposited at Gene Expression Omnibus (GEO ID: GSE58824) were associated with a recently published study by Song et al. (2014) in BMC Genomics. The authors describe the experimental data herein to build a platform for better understanding the toxic mechanisms and ecological hazard of radionuclides such as DU in fish.
Related Links	http://dx.doi.org/10.1016/j.gdata.2014.10.003
Ending Page	341
Page Count	2
Starting Page	340
File Format	PDF
ISSN	22135960
e-ISSN	22135960
Journal	Genomics Data
Volume Number	2
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	Elsevier
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Medicine Biotechnology

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