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25-vitamin D, 1,25-vitamin D, parathyroid hormone, fibroblast growth factor-23 and cognitive function in men with advanced CKD: a veteran population
| Content Provider | PubMed Central |
|---|---|
| Author | Jovanovich, Anna J. Michel, Chonchol Brady, Christopher B. Kaufman, James D. Kendrick, Jessica Cheung, Alfred K. Jablonski, Kristen L. |
| Copyright Year | 2014 |
| Abstract | Abstract. Cognitive impairment is common in advanced chronic kidney disease (CKD), but little is known about its relation with abnormalities in mineral metabolism. Methods: The longitudinal association between plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), intact parathyroid hormone (iPTH), and fibroblast growth factor-23 (FGF-23) levels and cognitive function was assessed in 605 patients (67 ± 12 years) with advanced CKD not requiring dialysis (n = 247) or end-stage renal disease (ESRD; n = 358) who participated in the Homocysteine Study Cognitive Function Substudy (HOSTCOG)). Cognitive function was assessed using the Telephone Interview for Cognitive Status-modified (TICSm; mean follow-up 3.1 years) and associated with baseline mineral metabolite levels using linear regression analyses. Results: In unadjusted analyses, increasing log 1,25(OH)2D and decreasing log iPTH and FGF-23 levels were associated with worse cognitive status (p < 0.05). In fully adjusted multivariate analyses, the associations were no longer significant. Log 25(OH)D levels were not associated with cognitive function in unadjusted or adjusted analyses. Results were similar when analyzed by tertile or separately within CKD and ESRD groups. Conclusions: These results suggest that mineral metabolism dysregulation does not mediate the impairment in cognitive function common in advanced CKD. |
| Related Links | http://dx.doi.org/10.5414/CN108365 |
| Ending Page | 303 |
| Page Count | 8 |
| Starting Page | 296 |
| File Format | |
| ISSN | 03010430 |
| Journal | Clinical Nephrology |
| Issue Number | 5 |
| Volume Number | 82 |
| Language | English |
| Publisher | Dustri-Verlag Dr. Karl Feistle |
| Publisher Date | 2014-11-01 |
| Access Restriction | Open |
| Rights Holder | Dustri-Verlag Dr. Karl Feistle |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
