NDLI: Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection

Content Provider	PubMed Central
Author	Wikramaratna, Paul S. Lourenço, José Klenerman, Paul Pybus, Oliver G. Gupta, Sunetra
Copyright Year	2015
Abstract	Despite substantial advances in our knowledge of immune responses against HIV-1 and of its evolution within the host, it remains unclear why control of the virus eventually breaks down. Here, we present a new theoretical framework for the infection dynamics of HIV-1 that combines antibody and CD8+ T-cell responses, notably taking into account their different lifespans. Several apparent paradoxes in HIV pathogenesis and genetics of host susceptibility can be reconciled within this framework by assigning a crucial role to antibody responses in the control of viraemia. We argue that, although escape from or progressive loss of quality of CD8+ T-cell responses can accelerate disease progression, the underlying cause of the breakdown of virus control is the loss of antibody induction due to depletion of CD4+ T cells. Furthermore, strong antibody responses can prevent CD8+ T-cell escape from occurring for an extended period, even in the presence of highly efficacious CD8+ T-cell responses.
Related Links	http://dx.doi.org/10.1098/rstb.2014.0290
Starting Page	20140290
File Format	PDF
ISSN	09628436
e-ISSN	14712970
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Issue Number	1675
Volume Number	370
Language	English
Publisher	The Royal Society
Publisher Date	2015-08-19
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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