NDLI: Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury

Content Provider	PubMed Central
Author	Pascal, Rowart Pauline, Erpicum Olivier, Detry Weekers, Laurent Grégoire, Céline Lechanteur, Chantal Briquet, Alexandra Beguin, Yves Krzesinski, Jean-marie Jouret, François
Copyright Year	2015
Abstract	Ischemia/reperfusion injury (IRI) represents a worldwide public health issue of increasing incidence. IRI may virtually affect all organs and tissues and is associated with significant morbidity and mortality. Particularly, the duration of blood supply deprivation has been recognized as a critical factor in stroke, hemorrhagic shock, or myocardial infarction, as well as in solid organ transplantation (SOT). Pathophysiologically, IRI causes multiple cellular and tissular metabolic and architectural changes. Furthermore, the reperfusion of ischemic tissues induces both local and systemic inflammation. In the particular field of SOT, IRI is an unavoidable event, which conditions both short- and long-term outcomes of graft function and survival. Clinically, the treatment of patients with IRI mostly relies on supportive maneuvers since no specific target-oriented therapy has been validated thus far. In the present review, we summarize the current literature on mesenchymal stromal cells (MSC) and their potential use as cell therapy in IRI. MSC have demonstrated immunomodulatory, anti-inflammatory, and tissue repair properties in rodent studies and in preliminary clinical trials, which may open novel avenues in the management of IRI and SOT.
Related Links	http://dx.doi.org/10.1155/2015/602597
Starting Page	602597
File Format	PDF
ISSN	23148861
e-ISSN	23147156
Journal	Journal of Immunology Research
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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