NDLI: Development of Protein Mimics for Intracellular Delivery

Content Provider	PubMed Central
Author	Deronde, Brittany M. Tew, Gregory N.
Abstract	Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoes become more complex, the need for improved delivery vehicles becomes critical. Excellent delivery vehicles must ensure the stability of the cargo, maintain the cargo’s solubility, and promote efficient delivery and release. In order to address these issues, many research groups have looked to nature for design inspiration. Proteins, such as HIV-1 TAT and Antennapedia homeodomain protein, are capable of crossing cellular membranes. However, due to the complexities of their structures, they are synthetically challenging to reproduce in the laboratory setting. Being able to incorporate the key features of these proteins that enable cell entry into simpler scaffolds opens up a wide range of opportunities for the development of new delivery reagents with improved performance. This review charts the development of protein mimics based on cell-penetrating peptides and how structure-activity relationships with these molecules and their protein counterparts ultimately led to the use of polymeric scaffolds. These scaffolds deviate from the normal peptide backbone, allowing for simpler, synthetic procedures to make carriers and tune chemical compositions for application specific needs. Successful design of polymeric protein mimics would allow researchers to further understand the key features in proteins and peptides necessary for efficient delivery and to design the next generation of more efficient delivery reagents.
Related Links	http://dx.doi.org/10.1002/bip.22658
Ending Page	280
Page Count	16
Starting Page	265
File Format	PDF
ISSN	10970282
e-ISSN	10970282
Journal	Biopolymers
Issue Number	4
Volume Number	104
Language	English
Publisher Date	2015-07-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Biomaterials Biochemistry Biophysics

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