NDLI: MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy

Content Provider	PubMed Central
Author	Jung, Monika Mollenkopf, Hans-joachim Grimm, Christina Wagner, Ina Albrecht, Marco Waller, Tobias Christian, Pilarsky Johannsen, Manfred Stephan, Carsten Hans, Lehrach Nietfeld, Wilfried Rudel, Thomas Jung, Klaus Kristiansen, Glen
Copyright Year	2009
Abstract	MicroRNAs are short single-stranded RNAs that are associated with gene regulation at the transcriptional and translational level. Changes in their expression were found in a variety of human cancers. Only few data are available on microRNAs in clear cell renal cell carcinoma (ccRCC). We performed genome-wide expression profiling of microRNAs using microarray analysis and quantification of specific microRNAs by TaqMan real-time RT-PCR. Matched malignant and non-malignant tissue samples from two independent sets of 12 and 72 ccRCC were profiled. The microarray-based experiments identified 13 over-expressed and 20 down-regulated microRNAs in malignant samples. Expression in ccRCC tissue samples compared with matched non-malignant samples measured by RT-PCR was increased on average by 2.7- to 23-fold for the hsa-miR-16, −452*, −224, −155 and −210, but decreased by 4.8- to 138-fold for hsa-miR-200b, −363, −429, −200c, −514 and −141. No significant associations between these differentially expressed microRNAs and the clinico-pathological factors tumour stage, tumour grade and survival rate were found. Nevertheless, malignant and non-malignant tissue could clearly be differentiated by their microRNA profile. A combination of miR-141 and miR-155 resulted in a 97% overall correct classification of samples. The presented differential microRNA pattern provides a solid basis for further validation, including functional studies.
Related Links	http://dx.doi.org/10.1111/j.1582-4934.2009.00705.x
Ending Page	3928
Page Count	11
Starting Page	3918
File Format	PDF
ISSN	15821838
e-ISSN	15824934
Journal	Journal of Cellular and Molecular Medicine
Issue Number	9b
Volume Number	13
Language	English
Publisher	John Wiley & Sons, Ltd
Publisher Date	2009-02-01
Access Restriction	Open
Rights Holder	John Wiley & Sons, Ltd
Subject Keyword	Molecular Medicine Cell Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Medicine

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